Models of Cellular Regulation
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Description
The human genome of three billion letters has been sequenced. So have the genomes of thousands of other organisms. With unprecedented resolution, modern technologies are allowing us to peek into the world of genes, biomolecules, and cells - and flooding us with data of immense complexity that we are just barely beginning to understand. A huge gap separates our knowledge of the components of a cell and what is known from our observations of its physiology. The authors have written this graduate textbook to explore what has been done to close this gap of understanding between the realms of molecules and biological processes. They have gathered together illustrative mechanisms and models of gene regulatory networks, DNA replication, the cell cycle, cell death, differentiation, cell senescence, and the abnormal state of cancer cells. The mechanisms are biomolecular in detail, and the models are mathematical in nature. The interdisciplinary presentation will be of interest to both biologists and mathematicians and every discipline in between.Features
- Comprehensive overview of known or putative molecular mechanisms, pathways, and networks regulating cellular physiology.
- Covers gene expression, DNA replication, cell cycle, death by apoptosis, differentiation, aging and renewal, and cancer.
- Describes how to formulate mathematical models that are firmly based on details of molecular biology.
- Shows how to perform mathematical analysis and computer simulation of complex biological networks.
- Illustrates multiscale modeling of cancer.
- Identifies open research problems.
Product Details
256 pages; 91 line drawings & halftones, 8 color images; 7-1/2 x 9-1/4; ISBN13: 978-0-19-857091-2ISBN10: 0-19-857091-0About the Author(s)
Baltazar Aguda is currently associate professor of Genetics & Genomics at the Boston University
School of Medicine. He holds joint appointments in Biomedical Engineering, in the Bioinformatics
& Systems Biology program at Boston University, and a membership in the Center for Biodynamics
in the same university. Recently, he was appointed member of the National Science
Foundation's (NSF, USA) research proposal review panel in molecular & cellular biosciences
(2004-7). He was a visiting faculty at the Mathematical Biosciences Institute at Ohio State University
(2003), at the Weizmann Institute of Science in Israel (2000), and a visiting associate at
the California Institute of Technology (2000-2001). Dr. Aguda obtained his PhD in Chemistry
(Chemical Physics Program) from the University of Alberta in Canada (1986), and was a tenured
faculty member of the Department of Chemistry & Biochemistry at Laurentian University in
Canada (1994-2002) before moving to Boston. Avner Friedman is a Distinguished Professor of Mathematics and Physical Sciences at
the Ohio State University, where he also serves as the Director of the Mathematical Biosciences
Institute. He received his Ph.D. degree in 1956 from the Hebrew University.
He was Professor of Mathematics at Northwestern University (1962-1985), and a Duncan
Distinguished Professor of Mathematics at Purdue University (1985-1987).
