Handbook on Syntheses of Amino Acids
General Routes to Amino Acids
ISBN13: 9780841272194ISBN10: 0841272190
Hardback,
1312 pages
Mar 2010,
Not Yet Published
Price:
$175.00 (06)See more from the series
Description
Amino acid synthesis is a field of research that has existed for over 150 years, but renewed interest has led to an exponential increase in publications in the past two decades. The Handbook on Syntheses of Amino Acids provides a comprehensive survey of synthetic procedures that prepare natural and unnatural amino acids in both racemic and optically active forms. The book begins with an introduction to amino acids, their properties, and anylytical techniques, including a detailed examination of methods used to establish enantiomeric configuration and optical purity. The next two chapters focus on processes for preparing racemic amino acids, dividing into those syntheses that introduce the amino and/or carboxy groups, and those that introduce the side chain. While some of these procedures date from the 1800s, modified versions are still extensively employed. A key component of these chapters is tables that summarize that summarize the many compounds made by each method. A chapter devoted to 2, 3-dehydroamino acids provides the bridge between racemic and asymmetric syntheses, as dehydroamino acids are themselvces achiral, but can be transformed into optically active products. Asymmetric amino acid preparations are then divided into six chapters, based on methods that introduce the amino and/or carboxy groups, those that introduce the side chains to acyclic synthons, those that introduce side chain to cyclic templates, those that open small ring systems, and those that derive the amino acided from other amino acids (with a separate chapter for serine-derived products). The growing field of non-?-amino acid synthesis is adressed in a separate chapter . The book is completed by a discussion of amino acids, including resolutions, N-alkylations, amidations and peptide couplings.Features
- Provides a complete summary of over 150 years of literature on amino acid synthesis
- Allows for easy identification of general approaches that may be suitable for particular amino acid syntheses
About the Author(s)
Mark Blaskovich is Chief Operating Officer at Mimetica, a peptidomimetic drug discovery company. An experienced industrial medicinal chemist, Mark has worked for CEPTYR Inc and the former peptide mimetics company Molecumetics.
