« Home

Home » Biosciences » Biochemistry » Taylor & Drickamer: Introduction to Glycobiology: 2e » Student resources » Key Reading References » Chapter 05

Taylor & Drickamer: Introduction to Glycobiology: 2e

Chapter 05

Key References

Anderson , R.G.W. (1998) The caveolae membrane system. Annual Review of Biochemistry 67, 199–225. This paper provides a detailed overview of caveolae and alternative routes of endocytosis.
http://arjournals.annualreviews.org/doi/full/10.1146/annurev.biochem.67.1.199

Brown, D.A. and London, E. (2000) Structure and function of sphingolipid- and cholesterol-rich membrane rafts. Journal of Biological Chemistry 275, 17221–17224. This is a short but detailed review of the evidence for the existence of membrane rafts, and their possible structures and functions.
http://www.jbc.org/cgi/reprint/275/23/17221.pdf

Hakomori, S. and Igarashi, Y. (1993) Gangliosides and glycosphingolipids as modulators of cell growth, adhesion and transmembrane signaling. Advances in Lipid Research 25, 147–162. This paper provides an overview of the cellular functions of glycolipids.
http://hyper.ahajournals.org/cgi/content/full/38/5/1030

Kinoshita, T., Ohishi, K., and Takeda, J. (1997) GPI-Anchor synthesis in mammalian cells: genes, their products and a deficiency. Journal of Biochemistry (Tokyo) 122, 251–257. Not available online.

Landolt-Marticorena, C. and Reithmeier, R.A.F. (1994) Asparagine-linked oligosaccharides are localised to single extracytosolic segments in multi-span membrane proteins. BiochemicalJournal 302, 253–260. This paper presents a survey of glycosylation sites in mammalian polytopic membrane proteins allowing general conclusions to be drawn. Not available online.

McConnville, M.J. and Ferguson, M.A.J. (1993) The structure, biosynthesis and function of glycosylated phosphatidyl inositols in the parasitic protozoa and higher eukaryotes. Biochemical Journal 294, 305–324. This paper provides a detailed overview of GPI anchored proteins. Not available online.

van Meer, G. (2001) What sugar next? Dimerization of sphingolipid glycosyltransferases. Proceedings of the National Academy of Sciences USA 98, 1321–1323. This is a short commentary on the mechanisms of glycosphingolipid synthesis.
http://www.pnas.org/cgi/reprint/98/4/1321.pdf

Schwarzmann, G. and Sandhoff, K. (1990) Metabolism and intracellular transport of glycosphingolipids. Biochemistry 29, 10865–10871. The biochemistry and cell biology of glycosphingolipid metabolism are reviewed.
http://pubs.acs.org/cgi-bin/archive.cgi/bichaw/1990/29/i49/pdf/bi00501a001.pdf

Stults, C.L.M., Sweeley, C.C., and Macher, B.A. (1989) Glycosphingolipids: structure, biological source and properties. Methods in Enzymology 179, 167–214. The chemistry and biochemistry of glycosphingolipids are reviewed in detail. Not available online.

Tomita, M. (1999) Biochemical background of paroxysmal nocturnal hemoglobinuria. Biochimica etBiophysica Acta 1455, 269–286. The genetic and biochemical basis for the symptoms of this glycolipid anchor deficiency disease are reviewed in detail.
[You must have a username and password to access the full article at http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T1Y-3XGFT0K-J-7&_cdi=4903&_user=217827&_orig=browse&_coverDate=10%2F08%2F1999&_sk=985449997&view=c&wchp=dGLbVtb-zSkWA&md5=06765de38a5f4d8b9cbdf9dce1a6a3b8&ie=/sdarticle.pdf]

Winchester , B.G. (1996) Lysosomal metabolism of glycoconjugates. Subcellular Biochemistry 27, 191–238. Glycolipid degradation and glycolipid storage disorders are reviewed. Not available online.

Yamashita, T., Wada, R., Sasaki, T., Deng, C., Bierfreund, U., Sandhoff, K., and Proia, P.L. (1999) A vital role for glycosphingolipid synthesis during development and differentiation. Proceedingsof the National Academy of Sciences USA 96, 9142–9147. This paper describes the phenotype of mice in which the gene for glucosylceramide synthase has been knocked out, preventing synthesis of glycosphingolipids.
http://www.pnas.org/cgi/reprint/96/16/9142.pdf

Questions

4) Discuss the evidence that gangliosides concentrated into plasma membrane micro-domains modulate signalling pathways.
Lead Reference: Allende, M.L. and Proia, R.L. (2002) Lubricating cell signalling pathways with gangliosides. Current Opinion in Structural Biology 12, 587-592.
[You must have a username and password to access the full article at http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6VS6-479TPX3-6-5&_cdi=6254&_user=217827&_orig=browse&_coverDate=10%2F01%2F2002&_sk=999879994&view=c&wchp=dGLbVlz-zSkzV&md5=4ad12a21fd015eb3f36fd9796db0f84c&ie=/sdarticle.pdf]

Box 5.1 Glycotherapeutics: Enzyme replacement and inhibitors of glycolipid synthesis can be used to treat storage diseases
Lead references:

Brady, R.O. (2003) Enzyme replacement therapy: conception, chaos and culmination. Philosphical Transactions of the Royal Society of London B, 358, 915-919.
http://www.journals.royalsoc.ac.uk/media/3d1xhx4jxq5uphderecn/contributions/b/1/t/j/b1tjfxlgmkwjnqcg.pdf

Ioannou, Y.A., Zeidner, K.M., Gordon, R.E. and Desnick, R.J. (2001) Fabry disease: Preclinical studies demonstrate the effectiveness of α-galactosidase A replacement in enzyme-deficient mice. American Journal of Human Genetics 68, 14-25.
http://www.journals.uchicago.edu/cgi-bin/resolve?AJHG002397PDF

Platt, F.M. and Butters, T.D. (2001) Substrate deprivation: A new therapeutic approach for the glycosphingolipid lysosomal storage diseases. Expert Reviews in Molecular Medicine Feb 1, 1-17.
http://journals.cambridge.org/action/displayFulltext?type=1&fid=170109&jid=&volumeId=&issueId=01&aid=170107

Platt, F.M., Neises, G.R., Dwek, R.A. and Butters, T.D. (1994) N-butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis. Journal of Biological Chemistry 269, 8362-8365.
http://www.jbc.org/cgi/reprint/269/11/8362.pdf

Box 5.2 Glycotherapeutics: Selective inhibition of glycolipid anchor biosynthesis may provide a way to treat African sleeping sickness
Lead references:

Ferguson, M.A.J. (2000) Glycosylphosphatidylinositol biosynthesis validated as a drug target for African sleeping sickness. Proceedings of the National Academy of Sciences USA 97, 10673-10675.
http://www.pnas.org/cgi/reprint/97/20/10673.pdf

Smith, T.K., Crossman, A., Borissow, C.N., Paterson, M.J., Dix, A., Brimacombe, J.S. and Ferguson, M.A.J. (2001) Specificity of the GlcNAc-PI de-N-acetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors. EMBO Journal 20, 3322-3332.
http://embojournal.npgjournals.com/cgi/reprint/20/13/3322.pdf

Smith, T.K., Crossman, A., Brimacombe, J.S. and Ferguson, M.A.J. (2004) Chemical validation of GPI biosynthesis as a drug target against African sleeping sickness. EMBO Journal 23, 4701-4708.
http://embojournal.npgjournals.com/cgi/reprint/23/23/4701.pdf

Grimme S.J., Colussi P.A., Taron C.H., and Orlean P. (2004) Deficiencies in the essential Smp3 mannosyltransferase block glycosylphosphatidylinositol assembly and lead to defects in growth and cell wall biogenesis in Candida albicans. Microbiology 150 , 3115-3128.
http://mic.sgmjournals.org/cgi/reprint/150/10/3115.pdf