Atkins & de Paula:
Physical Chemistry for the Life Sciences
The Michaelis-Menten model of the variation of the rate of an enzyme-catalysed reaction with concentration of the substrate is given by
Where S is the substrate concentration (mmol L-1), vmax is the maximum velocity (mmol s-1), and KM is the Michaelis constant (mmol L-1).
Notice that when S << KM, the rate is proportional to S; when S >> KM, the rate is independent of S.
To graph the variation of the reaction rate enter the parameters (i.e., vmax, KM) and hit New Plot.
Up to 5 plots can be displayed at one time. The Clear button will remove all plots. To see the parameters
for each plot hit the Legend on/off button. The Redraw button will refresh the graph. This is useful when
the function domain (i.e., S ) has been changed. To see the value of each plot at a given point, move your cursor
to the desired location then click and hold.