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Patrick: An Introduction to Medicinal Chemistry 4e
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What term is used to indicate the ability of a cancer to invade other parts of the body and to produce secondary tumours?
Which molecules are involved in the anchoring of cells to an extracellular matrix?
Cyclophosphamide is commonly used in anticancer therapy.Which of the following statements is not true of the above structure?
What is the name of the following anticancer drug?
The following structure is an inhibitor of the enzyme responsible for adding a farnesyl chain to the Ras protein. Which feature binds to the zinc cofactor of the enzyme?
The following structure is a natural product having anticancer properties, which was isolated from a marine worm. What is it called?
What is the term used to indicate the growth of new blood vessels?
Which of the following inhibits angiogenesis?
The tetracyclines act as intercalating anticancer agents.Which of the following is a simplified analogue of tetracyclines?
Pentostatin is a natural product used for the treatment of leukaemia. What is the role of the region shown in blue?
Imatinib is an important anticancer drug which targets a protein kinase. The piperazine ring has an important interaction with an amino acid in the binding site. Which amino acid is involved?
The following structure is called marimastat and is a matrix metalloproteinase inhibitor that has undergone clinical trials for the treatment of breast and prostate cancers. What role is played by the hydroxamic acid group?
The following structure is a natural product currently being studied as an anticancer agent. What is the name of the structure?
What sort of therapy involves administration of an antibody linked to an enzyme, such that the enzyme activates a prodrug?
