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Patrick: An Introduction to Medicinal Chemistry 4e

Chapter 15

Instructions

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Question 1

Which of the following areas of study is not part of preclinical trials?

Question 2

Which of the following terms is used to describe the dose of a drug required to produce a measurable effect in 50% of the animals tested?

Question 3

Which of the following terms is used to describe the dose of a drug required to kill 50% of a group of animals?

Question 4

What is meant by the therapeutic ratio or index?

Question 5

Which of the following techniques is the most suitable for detecting a metabolite labelled with 13C?

Question 6

Which of the following techniques would be used to detect a metabolite labelled with 3H?

Question 7

Which of the following techniques would be used to detect a metabolite labelled with 14C?

Question 8

Which of the following techniques would be used to detect a metabolite labelled with 2H?

Question 9

What problem might you foresee in labelling a drug as shown?
Figure 1

Question 10

What is the most likely problem that you can foresee in labelling a drug as shown? The functional group is an alcohol.
Figure 2

Question 11

What problem might you foresee in labelling a drug as shown?
Figure 3

Question 12

What problem might you foresee in labelling a drug as shown?
Figure 4

Question 13

What sort of factors might affect the stability of a compound in a pharmaceutical preparation?

Question 14

What term is used to describe the patenting of the active enantiomer of a racemic drug which is already on the market?

Question 15

What term is applied to a drug which is effective against a relatively rare medical problem?