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Question 1

Which of the following statements is true regarding amphotericin?

Amphotericin

a) The blue region is a hydrophilic region that interacts with the phospholipid bilayer of cell membranes by van der Waals interactions.

b) Several molecules of amphotericin self-assemble to form a hydrophobic tunnel through the cell membrane. The tunnel interior is lined with non polar functional groups.

c) The amphotericin molecule is the ideal length to span the cell membrane.

d) Amphotericin acts as an antifungal drug by allowing the uncontrolled passage of ions and water across the cell membrane.

Question 2

Which of the following statements is untrue about glycosphingolipids?

a) Glycosphingolipids are responsible for labelling red blood cells as A, B, AB or O.

b) Glycosphingolipids can act as antigens.

c) Glycosphingolipids are made up of a carbohydrate, a fatty acid, and sphingosine.

d) Glycosphingolipids contain a hydrophobic carbohydrate group, which acts as a molecular tag for red blood cells.

Question 3

What is the major clinical use of selective serotonin reuptake inhibitors?

a) analgesics

b) Antiobesity agents

c) antidepressants

d) Antimigraine agents

Question 4

What is the molecular target for the vinca alkaloids used as anticancer agents?

a) The transport protein for serotonin

b) DNA

c) Cell membrane

d) Tubulin

Question 5

Which of the following statements is not true?

a) Some polar drugs can be designed such that they are carried across cell membranes by transport proteins.

b) Tricyclic antidepressants act by blocking the transport proteins that normally transport noradrenaline back into nerve cells.

c) Designing drugs to block transport proteins can be useful in medicine.

d) The actions of cocaine are a result of it being carried into cells by transport proteins.

Question 6

The structure shown is an important anticancer agent which targets the structural protein tubulin. What is the name of the structure.

a) BMS 188797

b) Ortataxel

c) Docetaxel

d) Paclitaxel

Question 7

The structure below is paclitaxel which is an important anticancer agent. Which group influences the activity of the drug against drug-resistant strains of cancers?

a) The side chain

b) The acyl group at position 10

c) The benzoyl group

d) The acetyl group

Question 8

The structure below is paclitaxel which is an important anticancer agent. Introducing a simple methyl subtituent has been found to increase activity if it is placed at a certain position. Which position?

a) C-2' of the side chain

b) C-10 of the core ring structure

c) C-13 of the core ring structure

d) The aromatic ring of the benzoyl substituent

Question 9

The following structure is called puromycin. What mode of action does it have?

a) It binds to a transport protein and prevents the reuptake of serotonin.

b) It binds to tubulin and prevents the formation of microtubules.

c) It acts as a chain terminator in protein synthesis.

d) It acts as protein-protein binding inhibitor.

Question 10

The following structure is an example of a group of compounds which mimic the amino acid residues that are crucial in certain protein-protein binding interactions. What is the name given to these structures?

a) Nutlins

b) Taxoids

c) Integrins

d) Antibodies

Oxford University Press, Online Resource Centre, Chapter 10.

Chapter 10

Instructions