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Question 1

Which of the following terms is used to describe a drug that has the same effect on a receptor as the endogenous chemical messenger?

a) agonist

b) antagonist

c) partial agonist

d) inverse agonist

Question 2

Which of the following terms is used to describe a drug that binds to a receptor, and activates it, but to a lesser extent than the endogenous chemical messenger?

a) agonist

b) antagonist

c) partial agonist

d) inverse agonist

Question 3

Which of the following terms is used to describe a drug that binds to a receptor, fails to activate it and prevents the endogenous chemical messenger from binding?

a) agonist

b) antagonist

c) partial agonist

d) inverse agonist

Question 4

Which of the following terms is used to describe a drug that binds to a receptor, fails to activate it and leads to a drop in inherent biological activity?

a) agonist

b) antagonist

c) partial agonist

d) inverse agonist

Question 5

Which of the following is not a crucial requirement for a drug to act as an agonist?

a) Functional groups

b) Metabolic stability

c) Pharmacophore

d) Size

Question 6

Which of the following terms applies to the maximum biological effect resulting from a drug binding to its target?

a) affinity

b) efficacy

c) potency

d) stability

Question 7

Which of the following terms is the measure of how strongly a drug binds to a receptor?

a) affinity

b) efficacy

c) potency

d) stability

Question 8

Which of the following terms applies to the amount of drug required to produce a defined biological effect?

a) affinity

b) efficacy

c) potency

d) stability

Question 9

An agonist contains an alcohol, amine and aromatic ring, all of which act as binding groups. Which of the following modifications is most likely to result in an antagonist?

a) Converting the alcohol to a methyl ether.

b) Adding an extra aromatic ring to the structure.

c) Synthesising an analogue which lacks the aromatic ring.

d) Converting the amine to an amide.

Question 10

When an agonist binds to a receptor for a long period of time, it can result in a phosphorylation reaction occurring, Which of the following terms is the most relevant description of the immediate effect?

a) Tolerance

b) Dependence

c) Sensitization

d) Desensitization

Oxford University Press, Online Resource Centre, Chapter 08.

Chapter 08

Instructions

Question 1

Question 2

Question 3

Question 4

Question 5

Question 6

Question 7

Question 8

Question 9

Question 10