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Question 1

What type of molecule is the following structure?

a) A protein.

b) A nucleic acid.

c) A phospholipid.

d) A carbohydrate.

Question 2

Which of the following is an accurate description of the phospholipid bilayer in cell membranes?

a) It is made up of two layers of phospholipid polymers.

b) It is made up of two layers of phospholipid molecules with the tails pointing away from each other.

c) It is made up of two layers of phospholipid molecules with the tails lying parallel to each other.

d) It is made up of two layers of phospholipid molecules with the tails interacting with each other.

Question 3

Which of the following statements is true regarding the phospholipid bilayer in cell membranes?

a) Water and ions are unable to cross the bilayer due to the charges present in the head groups.

b) Water and ions are unable to cross the bilayer due to the hydrophobic tails of the phospholipid molecules.

c) Water and ions are encouraged to cross the bilayer by interacting with the charges present in the head groups.

d) The molecules in the bilayer are fluid, and so the cell membrane is porous allowing the passage of ions and water across the cell membrane.

Question 4

Which of the following statements is true?

a) Drugs and drug targets generally have similar molecular weights.

b) Drugs are generally smaller than drug targets.

c) Drugs are generally larger than drug targets.

d) There is no general rule regarding the relative size of drugs and their targets.

Question 5

What is meant by a binding site?

a) The area of a macromolecular target that is occupied by a drug when it binds.

b) The portion of the drug to which a drug target binds.

c) The functional groups used by a drug in binding to a drug target.

d) The bonds involved in binding a drug to its target.

Question 6

Consider the molecule in blue bound to a binding site. Identify the binding interactions taking place at i and iv shown in red.

a) hydrogen bonds

b) ionic bonds

c) van der Waals interactions

Question 7

Consider the molecule in blue bound to a binding site. Identify the binding interactions taking place at iii shown in red.

a) hydrogen bonds

b) ionic bonds

c) van der Waals interactions

Question 8

Consider the molecule in blue bound to a binding site. Identify the binding interactions taking place at ii shown in red.

a) hydrogen bonds

b) ionic bonds

c) van der Waals interactions

Question 9

Which of the following binding interactions is likely to be the most important initial interaction when a drug enters a binding site?

a) van der Waals interactions

b) hydrogen bond

c) ionic

d) induced dipole-dipole interactions

Question 10

Which of the following underlined atoms is likely to be the strongest hydrogen bond acceptor?

a) amide nitrogen (RNHCOR')

b) aniline nitrogen (ArNH₂)

c) amine nitrogen (RNH₂)

d) carboxylate oxygen (RCO₂^-)

Question 11

Which of the following underlined protons is likely to be the strongest hydrogen bond donor?

a) alcohol (ROH)

b) amine (RNH₂)

c) phenol (ArOH)

d) ammonium ion (RNH₃⁺)

Question 12

Which of the following functional groups is most likely to participate in a dipole-dipole interaction?

a) Aromatic ring

b) Ketone

c) Alcohol

d) Alkene

Question 13

Which of the following statements is untrue?

a) Desolvation is an energy expensive process that involves the removal of water from polar functional groups prior to a drug binding to its binding site.

b) Water molecules surrounding a hydrophobic region of a drug form an ordered layer of molecules with low entropy.

c) Interaction between the non polar regions of a drug and the non polar regions of a target require the removal of an ordered water coat and represents a gain in binding energy due to increased entropy.

d) An increase in entropy results in a greater positive value of ΔG and a greater chance of binding.

Oxford University Press, Online Resource Centre, Chapter 01.

Chapter 01

Instructions

Question 1

Question 2

Question 3

Question 4

Question 5

Question 6

Question 7

Question 8

Question 9

Question 10

Question 11

Question 12

Question 13