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Patrick: An Introduction to Medicinal Chemistry 4e

Chapter 11

Further reading

Bottorff, M, and Hansten, P. (2000) Long-term safety of hepatic hydroxymethyl glutaryl coenzyme A reductase inhibitors. Archives of Internal Medicine, 160, 2273-2280 [DOI: 10.1001/archinte.160.15.2273] [PubMed: 10927723].

Jain, K. S., et al. (2007) The biology and chemistry of hyperlipidemia. Bioorganic and Medicinal Chemistry, 15, 4674-4699 [DOI: 10.1016/j.bmc.2007.04.031] [PubMed: 17521912].

Istvan, E. S., et al. (2000) Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis. The EMBO Journal, 19, 819-830 [DOI: 10.1093/emboj/19.5.819] [PubMed: 10698924].

Istvan, E. S., and Deseinhofer, J. (2001) Structural mechanisms for statin inhibition of HMG-CoA reductase. Science, 292, 1160-1164 [DOI: 10.1126/science.1059344].

Istvan, E. (2003) Statin inhibition of HMG-CoA reductase: a 3-dimensional view. Atherosclerosis Supplements, 4, 3-8 [DOI: 10.1016/S1567-5688(03)00003-5].

Tobert, J. A. (2003) Lovastatin and beyond: The history of the HMG-CoA reductase inhibitors. Nature Reviews Drug Discovery, 2, 517-526 [DOI: 10.1038/nrd1112] [PubMed: 12815379].