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Which of the following statements about the role of the pentose phosphate pathway is correct?

a) The pentose phosphate pathway produces ribose-5-phosphate and NADPH.

b) The pentose phosphate pathway oxidises glucose-6-phosphate completely to carbon dioxide and water.

c) The rate-limiting reaction of the pentose phosphate pathway is catalyzed by transketolase.

d) The pentose phosphate pathway occurs in the mitochondria of most cells.

Which of the following statements about the oxidative section of the pentose phosphate pathway is correct?

a) The pentose phosphate pathway generates NADH.

b) The pentose phosphate pathway oxidizes NADPH to NADP⁺.

c) The rate-limiting reaction of the pentose phosphate pathway is catalyzed by glucose-6-phosphatase.

d) The pathway supplies ribose-5-phosphate and NADPH in the quantities the cells require.

Which of the following statements about the nonoxidative section of the pentose phosphate pathway is correct?

a) The nonoxidative reactions of the pentose phosphate pathway are not reversible.

b) Transketolase is an enzyme that transfers three-carbon units in the pentose phosphate pathway.

c) Transaldolase is an enzyme that transfers two-carbon units in the pentose phosphate pathway.

d) Pentoses undergo isomerizations in the pentose phosphate pathway.

Which of the following statements about the use of the NADPH generated from the pentose phosphate pathway is not correct?

a) NADPH generated from the pentose phosphate pathway is used for steroid synthesis.

b) NADPH generated from the pentose phosphate pathway is used for the regeneration of glutathione to its reduced state.

c) NADPH generated from the pentose phosphate pathway is used for the synthesis of fatty acids.

d) NADPH generated from the pentose phosphate pathway and cytoplasmic NADH are metabolically interchangeable.

Which of the following statements about the pentose phosphate pathway is not correct?

a) The pentose phosphate pathway relies on the availability of NADP⁺.

b) The pentose phosphate pathway has an irreversible oxidative section and a reversible non oxidative section.

c) The pentose phosphate pathway enables excess ribose to be metabolised.

d) The pentose phosphate pathway relies on the availability of NADPH.

Oxford University Press, Online Resource Centre, Chapter 17.