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Pecorino: Molecular Biology of Cancer 2e

Chapter 05

Further reading

Adams, P.D. (2001) Regulation of the retinoblastoma tumor suppressor protein by cyclin/cdks. Biochim. Biophys. Acta 1471: M123-M133. [PubMed: 11250068]

Classon, M. and Harlow, E. (2002) The retinoblastoma tumor suppressor in development and cancer. Nature Rev. Cancer 2: 910-917. [DOI: 10.1038/nrc950]

Collins, I. and Garrett, M.D. (2005) Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors. Curr. Opin. Pharmacol. 5: 366-373. [PubMed: 15964238] [DOI: 10.1016/j.coph.2005.04.009]

DiCiommo, D., Gallie, B.L., and Bremner, R. (2000) Retinoblastoma: the disease, gene and protein provide critical leads to understand cancer. Semin. Cancer Biol. 10: 255-269. [PubMed: 10966849] [DOI: 10.1006/scbi.2000.0326]

Fischer, P.M. and Gianella-Borradori, A. (2003) CDK inhibitors in clinical development for the treatment of cancer. Expert Opin. Invest. Drugs 12: 955-970. [DOI: 10.1517/13543784.12.6.955]

Kaufmann, W.K. (2006) Dangerous entanglements. Trends Mol. Med. 12: 235-237. [PubMed: 16631407] [DOI: 10.1016/j.molmed.2006.04.001]

Kops, G.J.P.L., Weaver, B.A.A., and Cleveland, D.W. (2005) On the road to cancer: aneuploidy and the mitotic checkpoint. Nature Rev. Cancer 5: 773-785. [DOI: 10.1038/nrc1714]

Malumbres, M. and Barbacid, M. (2001) To cycle or not to cycle: a critical decision in cancer. Nature Rev. Cancer 1: 222-231. [DOI: 10.1038/35106065]

Massagué J. (2004) G1 cell-cycle control and cancer. Nature 432: 298-306. [DOI: 10.1038/nature03094]

Meraldi, P., Honda, R., and Nigg, E.A. (2004) Aurora kinases link chromosome segregation and cell division to cancer susceptibility. Curr. Opin. Genet. Dev. 14: 29-36. [PubMed: 15108802] [DOI: 10.1016/j.gde.2003.11.006]

Shah, M.A. and Schwartz, G.K. (2006) Cyclin dependent kinases as targets for cancer therapy. Update Cancer Ther. 1: 311-332. [DOI: 10.1016/j.uct.2006.08.001]

Swanton, C. (2004) Cell-cycle targeted therapies. Lancet Oncol. 5: 27-36. [PubMed: 14700606] [DOI: 10.1016/S1470-2045(03)01321-4]

Weaver, B.A.A. and Cleveland, D.W. (2005) Decoding the links between mitosis, cancer and chemotherapy: the mitotic checkpoint, adaptation, and cell death. Cancer Cells 8: 7-12. [DOI: 10.1016/j.ccr.2005.06.011]

Zhu, L. (2005) Tumour suppressor retinoblastoma protein Rb: a transcriptional regulator. Eur. J. Cancer 41: 2415-2427. [PubMed: 16209920] [DOI: 10.1016/j.ejca.2005.08.009]

Selected Special Topics

Emanuel, S., Rugg, C.A., Gruninger, R.H., Lin, R., Fuentes-Pesquera, A., Connolly, P.J., Wetter, S.K., Hollister, B., Kruger, W.W., Napier, C., Jolliffe, L., and Middleton, S.A. (2005) The in vitro and in vivo effects of JNJ-7706621: A dual inhibitor of cyclin-dependent kinases and aurora kinases. Cancer Res. 65: 9038-9046. [PubMed: 16204078] [DOI: 10.1158/0008-5472.CAN-05-0882]

Ewart-Toland, A., Briassouli, P., de Koning, J.P., Mao, J.-H., Yuan, J., Chan, F., MacCarthy-Morrogh, L., Ponder, B.A.J., Nagase, H., Burn, J., Ball, S., Almeida, M., Linardopoulos, S., and Balmain, A. (2003) Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nature Genet. 34: 403-412. [PubMed: 12881723] [DOI: 10.1038/ng1220]

Reed, S.I. (2003) Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover. Nature Rev. Mol. Cell Biol. 4: 855-864. [DOI: 10.1038/nrm1246]

Roy, P.G. and Thompson, A.M. (2006) Cyclin D1 and breast cancer. The Breast 15: 718-727. [PubMed: 16675218] [DOI: 10.1016/j.breast.2006.02.005]

Rubin, S.M., Gall, A.-L., Zheng, N., and Pavletich, N.P. (2005) Structure of the Rb C-terminal domain bound to E2F-DP1: A mechanism for phosphorylation-induced E2F release. Cell 123: 1093-1106. [PubMed: 16360038] [DOI: 10.1016/j.cell.2005.09.044]

Sanchez, I. and Dynlacht, B.D. (2005) New insights into cyclins, CDKs, and cell cycle control. Semin. Cell Dev. Biol. 16: 311-321. [PubMed: 15840440] [DOI: 10.1016/j.semcdb.2005.02.007]

Senderowicz, A.M. (2003) Small-molecule cyclin-dependent kinase modulators. Oncogene 22: 6609-6620. [PubMed: 14528286] [DOI: 10.1038/sj.onc.1206954]

Sharpless, N.E., Bardeesy, N., Lee, K.H., Carrasco, D., Castrillon, D.H., Aguirre, A.J., Wu, E.A., Horner, J.W., and De Pinho, R.A. (2001) Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature 413: 86-91. [DOI: 10.1038/35092592]

Sherr, C.J. (2000) The Pezcoller Lecture: cancer cell cycles revisited. Cancer Res. 60: 3689-3695. [PubMed: 10919634]

Utikal, J., Udart, M., Leiter, U., Kaskel, P., Peter, R.U., and Krahn, G. (2005) Numerical abnormalities of the Cyclin D1 gene locus on chromosome 11q13 in non-melanoma skin cancer. Cancer Lett. 219: 197-204. [PubMed: 15723720] [DOI: 10.1016/j.canlet.2004.07.011]