Chapter 02

C. elegans Sequencing Consortium (1999). How the worm was won. The C. elegans genome sequencing project. Trends in Genetics, 15, 51-58. Description of the project in which high-throughput DNA sequencing was originally developed, and its results, the first metazoan genome to be sequenced. [DOI: 10.1016/S0168-9525(98)01666-7]

Ashburner, M. (2006). Won for All: How The Drosophila In: Genome Was Sequenced. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. A personal description-a 'blow-by-blow' account-of the fly genome project.

Ureta-Vidal, A., Ettwiller, L. and Birney, E. (2003). Comparative genomics: genomewide analysis in metazoan eukarya. Nature Reviews Genetics, 4, 251-262. Introduction to the repertoire of solved genomes and how genomes from different species illuminate one another. [PubMed: 12671656] [DOI: 10.1038/nrg1043]

Zhang, R. and Zhang, C.-T. (2006). The impact of comparative genomics on infectious disease research. Microbes and Infection, 8, 1613-1622. How comparative genomics of prokaryotes is elucidating infectious disease, including identification of virulence determinants, drug targets, candidate vaccines and diagnostic markers. [PubMed: 16697228] [DOI: 10.1016/j.micinf.2005.11.019]

Doolittle, W.F. (1999). Lateral genomics. Trends in Cell Biology, 9, M5-M8. How the discovery of horizontal gene transfer has upset traditional views of evolution.

Koonin, E.V. (2000). How many genes can make a cell?: the minimal-gene-set concept. Annual Review of Genomics and Human Genetics, 1, 99-116. A summary of work on comparative genomics. [PubMed: 11701626] [DOI: 10.1146/annurev.genom.1.1.99]

Kwok, P.-Y. and Gu, Z. (1999). SNP libraries: why and how are we building them? Molecular Medicine Today 5, 538-543. Progress and rationale for databases of single-nucleotide polymorphisms. [PubMed: 10562720] [DOI: 10.1016/S1357-4310(99)01601-9]

Southan, C. (2004). Has the yo-yo stopped? An assessment of human protein-coding gene number. Proteomics, 4, 1712-1726. How many genes are there in the human genome? Estimates have been changing. [DOI: 10.1002/pmic.200300700]

Bentley, D.R. (2004). Genomes for medicine. Nature, 429, 440-445. Summary and discussion of the results of genomic sequencing and their applications. [DOI: 10.1038/nature02622]

Dubcovsky, J. and Dvorak, J. (2007). Genome plasticity a key factor in the success of polyploid wheat under domestication. Science 316, 1862-1866. [PubMed: 17600208] [DOI: 10.1126/science.1143986]

Publications of the drafts of the human genome sequences appeared in special issues of Nature, 15 February 2001, containing the results of the publicly supported Human Genome Project, and Science, 16 February 2001, containing the results produced by Celera Genomics. These are landmark issues.

The May 2001 issue of Genome Research, Volume 11, Number 5, is devoted to the human genome.

The completion of the human genome in 2003 was announced in various press releases, and described in issues of Nature and Science magazines:

Collins, F.S., Green, E.D., Guttmacher, A.E. and Guyer, M.S. (2003). A vision for the future of genomics research. Nature, 422, 835-847. [DOI: 10.1038/nature01626]

Building on the DNA Revolution. (2003). Special section, Science, 300, 11 April 2003, pp. 277ff.

Xu, J. (2006). Microbial ecology in the age of genomics and metagenomics: concepts, tools and recent advances. Molecular Ecology, 15, 1713-1731. [PubMed: 16689892] [DOI: 10.1111/j.1365-294X.2006.02882.x]

Eisen, J.A. (2007) Environmental shotgun sequencing: its potential and challenges for studying the hidden world of microbes. PLoS Biology, 5, e82 Two papers discussing the current status and conceptual problems of coming to terms with metagenomics. [PubMed: 17355177] [DOI: 10.1371/journal.pbio.0050082]

Oxford University Press, Online Resource Centre, Chapter 02.

Chapter 02