Immunity: Chapter 08, Specialized Lymphocytes in Early Responses and Homeostasis

Which of the following receptors of NK cells transmit(s) activating signals on recognition of stress-related non-classical MHC class I molecules?

	a)	CD94/NKG2A
	b)	NKG2D
	c)	NKp30
	d)	CD16
correctWrong: b is correct.Your answer has been saved.

Which of the following statements are true?

	a)	Both mouse and human activating receptors of NK cells signal through DAP12.
	b)	CD94/NKG2A signals through the SH2-containing adaptor protein SAP.
	c)	Inhibitory receptors of NK cells recruit SHP phosphatases that suppress activation by the activating receptors.
	d)	The difference between activating and inhibitory receptors of NK cells is in their cytoplasmic domains which recruit different downstream signaling molecules.
	e)	HLA-E signals normal expression of MHC class I by specifically binding so-called leader peptides derived from it and without which it cannot reach the cell surface.
	f)	Qa-1 signals normal expression of MHC class I by specifically binding so-called leader peptides derived from it and without which it cannot reach the cell surface.
	g)	CD16 is the FcγRIII receptor.
	h)	The FcγRIII receptor activates antibody-mediated cellular cytotoxicity (ADCC) by NK cells.
CorrectWrong: a c d e f g and h are trueYour answer has been saved.

NK cell cytotoxicity is suppressed by inhibitory receptors that recognize molecules that are present on the surface of healthy cells and is activated by receptors recognizing molecules that are expressed on stressed or infected cells. Which of the receptors below inhibit(s) cytotoxicity on recognition of non-classical MHC molecules that bind peptides from classical MHC class I molecules, which are expressed on healthy cells?

	a)	NKG2D
	b)	KLRG1
	c)	CD94/NKG2A
	d)	NKp44
CorrectWrong: c is correct.Your answer has been saved.