Immunity: Chapter 07, Development of Lymphocytes and Selection of the Receptor Repertoire

Table of Contents

1. 7-1 Overview of Lymphocyte Development
2. 7-2 V(D)J Recombination: Mechanism of Recombination
3. 7-3 V(D)J Recombination: Control of which Segments Recombine
4. 7-4 Phylogenetic Diversity in Antigen Receptor Genes
5. 7-5 B Cell Development in the Bone Marrow
6. 7-6 Maturation of B Cells in the Periphery
7. 7-7 Organization of the Thymus and Early T Cell Development
8. 7-8 Positive Selection of T Cells in the Thymus
9. 7-9 Proposed Mechanisms of Positive Selection
10. 7-10 Negative Selection
11. 7-11 Diseases Related to Lymphocyte Development

7-7 Organization of the Thymus and Early T Cell Development

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

Which of the following statements are true? a) Double-negative thymocytes give rise to double-positive thymocytes as development progresses. b) Double-negative and double-positive thymocytes are located primarily in the medulla of the thymus. c) Double-positive thymocytes express CD4 and CD8. d) The only antigen presenting cell type in the thymus is the dendritic cell. e) Double negative thymocytes can give rise to either T cells with αβ TCRs or to T cells with γδ TCRs. f) The pre-TCR participates in development of αβ T cells and not in the development of γδ T cells. g) Pre-TCR signaling is triggered by its interaction with a ligand found only on medullary epithelial cells. h) Pre-TCR signaling requires the protein tyrosine kinases Lck and ZAP-70. i) The TCR γ chain pairs with pre-TCRα chain to form the pre-TCR. j) Individuals with DiGeorge syndrome lack a thymus. k) Interleukin 7 is a necessary survival factor for thymocytes. l) During the development of αβ T cells, TCR α rearranges before TCR β. CorrectWrong: a, c, e, f, h, j and k are true.Your answer has been saved.