Immunity: Chapter 07, Development of Lymphocytes and Selection of the Receptor Repertoire

Table of Contents

1. 7-1 Overview of Lymphocyte Development
2. 7-2 V(D)J Recombination: Mechanism of Recombination
3. 7-3 V(D)J Recombination: Control of which Segments Recombine
4. 7-4 Phylogenetic Diversity in Antigen Receptor Genes
5. 7-5 B Cell Development in the Bone Marrow
6. 7-6 Maturation of B Cells in the Periphery
7. 7-7 Organization of the Thymus and Early T Cell Development
8. 7-8 Positive Selection of T Cells in the Thymus
9. 7-9 Proposed Mechanisms of Positive Selection
10. 7-10 Negative Selection
11. 7-11 Diseases Related to Lymphocyte Development

7-6 Maturation of B Cells in the Periphery

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

Which of the following statements are true? a) Transitional B cells contacting an antigen that induces high level BCR signaling are induced to undergo apoptosis. b) B cells become anergic if they fail to interact with self antigens. c) There are three types of long-lived mature B cells: B1 cells, marginal zone B cells, and follicular B cells. d) Notch2 signaling is required for follicular B cell development. CorrectWrong: a and c are true.Your answer has been saved.

2

Which of the following are features of BAFF? a) Membership of the TNF family. b) Promotion of mature follicular and marginal zone B cell survival. c) Production by T cells and not by myeloid cells. d) Delivery of survival signals to long-lived plasma cells. CorrectWrong: a, b and d are correct.Your answer has been saved.