Immunity: Chapter 07, Development of Lymphocytes and Selection of the Receptor Repertoire

Table of Contents

1. 7-1 Overview of Lymphocyte Development
2. 7-2 V(D)J Recombination: Mechanism of Recombination
3. 7-3 V(D)J Recombination: Control of which Segments Recombine
4. 7-4 Phylogenetic Diversity in Antigen Receptor Genes
5. 7-5 B Cell Development in the Bone Marrow
6. 7-6 Maturation of B Cells in the Periphery
7. 7-7 Organization of the Thymus and Early T Cell Development
8. 7-8 Positive Selection of T Cells in the Thymus
9. 7-9 Proposed Mechanisms of Positive Selection
10. 7-10 Negative Selection
11. 7-11 Diseases Related to Lymphocyte Development

7-5 B Cell Development in the Bone Marrow

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

Which of the following statements are true? a) Early B lineage development is characterized by the activation of a cascade of transcriptional regulators that are responsible for expression of genes with specialized functions in B cells. b) The transcriptional regulator Pax5 turns on B cell-specific genes and represses several genes required to develop down other hematopoietic lineages. c) Receptor editing is a mechanism of changing the antigen specificity of developing B cells that react to self antigens. d) RAG-1 and RAG-2 participate in receptor editing. CorrectWrong: a, b, c and d are true.Your answer has been saved.

2

Which of the following are functional properties of signaling from the pre-BCR? a) Stimulation of cytokine-independent growth of pre-B cells. b) Stimulation of Ig light chain locus rearrangements. c) Requirement for Btk in order to induce development past the pre-B cell stage in humans. d) inhibition by the action of the surrogate light chain. CorrectWrong: b and c are correct.Your answer has been saved.