Immunity: Chapter 07, Development of Lymphocytes and Selection of the Receptor Repertoire

Table of Contents

1. 7-1 Overview of Lymphocyte Development
2. 7-2 V(D)J Recombination: Mechanism of Recombination
3. 7-3 V(D)J Recombination: Control of which Segments Recombine
4. 7-4 Phylogenetic Diversity in Antigen Receptor Genes
5. 7-5 B Cell Development in the Bone Marrow
6. 7-6 Maturation of B Cells in the Periphery
7. 7-7 Organization of the Thymus and Early T Cell Development
8. 7-8 Positive Selection of T Cells in the Thymus
9. 7-9 Proposed Mechanisms of Positive Selection
10. 7-10 Negative Selection
11. 7-11 Diseases Related to Lymphocyte Development

7-2 V(D)J Recombination: Mechanism of Recombination

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

Which of the following statements are true? a) RAG-1 and RAG-2 bind to recombination signal sequences to initiate V(D)J recombination. b) Genetic deficiencies of RAG-1 or RAG-2 result in severe immunodeficiency. c) Junctional diversity is created by inserting nucleotides into the signal joint. d) An intermediate in V(D)J recombination is a hairpin-containing DNA molecule. CorrectWrong: a, b and d are true.Your answer has been saved.

2

Which of the following processes contribute(s) to junctional diversity? a) Insertion of N regions by terminal deoxynucleotidyl transferase (TdT). b) Insertion of P regions resulting from asymmetric cleavage of the hairpin intermediate in the coding joint by Artemis. c) The ability of each different Ig heavy chain to combine with many different Ig light chains. d) The 12/23 rule CorrectWrong: a and b are correct.Your answer has been saved.