Immunity: Chapter 07, Development of Lymphocytes and Selection of the Receptor Repertoire

Table of Contents

1. 7-1 Overview of Lymphocyte Development
2. 7-2 V(D)J Recombination: Mechanism of Recombination
3. 7-3 V(D)J Recombination: Control of which Segments Recombine
4. 7-4 Phylogenetic Diversity in Antigen Receptor Genes
5. 7-5 B Cell Development in the Bone Marrow
6. 7-6 Maturation of B Cells in the Periphery
7. 7-7 Organization of the Thymus and Early T Cell Development
8. 7-8 Positive Selection of T Cells in the Thymus
9. 7-9 Proposed Mechanisms of Positive Selection
10. 7-10 Negative Selection
11. 7-11 Diseases Related to Lymphocyte Development

7-1 Overview of Lymphocyte Development

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

Which of the following statements are true? a) Immunoglobulin and T cell receptor chains are encoded in the germ line in discrete segments that are brought together in lymphocyte precursors to generate functional genes. b) Combinatorial diversity of immunoglobulins is generated by imprecise junctions between rearranging gene segments. c) Approximately 2 out of every 3 rearrangements of the Ig κ locus are non-functional due to the variability in the numbers of nucleotides inserted or deleted at the junction between the V and J segments. d) The Ig heavy chain locus has three types of rearranging gene segments called V, D and J. e) Rearrangements of Ig loci are initiated by RAG-1, whereas rearrangements of TCR loci are initiated by RAG-2. f) V(D)J recombination is completed by the non-homologous DNA end joining pathway of DNA repair. g) The 12/23 rule refers to the relative numbers of V segments and J segments in an Ig or TCR locus. h) V and J segments have recombination signal sequences on one end of the gene segment, whereas D segments have recombination signal sequences on both ends. CorrectWrong: a, c, d, f and h are true.Your answer has been saved.