Immunity: Chapter 06, B Cells and Humoral Immunity

Table of Contents

1. 6-1 Structure of Antibodies
2. 6-2 Structural Properties of Antibodies
3. 6-3 Effector Functions of Antibodies
4. 6-4 Monoclonal Antibodies
5. 6-5 Antibody-Based Methods: Radioimmunoassay and Hemagglutination
6. 6-6 Antibody-Based Methods: ELISA, Immunoblotting and FACS
7. 6-7 Antigen Receptors of B Lymphocytes
8. 6-8 B Cell Antigen Receptor Signaling and B Cell Coreceptors
9. 6-9 Early and T Cell-Independent Antibody Responses by B Cells
10. 6-10 Initiation of T Cell-Dependent Antibody Responses
11. 6-11 Hypermutation and Isotype Switching in the Germinal Center
12. 6-12 Selection and Differentiation of B Cells in the Germinal Center

6-12 Selection and Differentiation of B Cells in the Germinal Center

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

Which of the following participate in selection of germinal center B cells for high affinity for antigen, ultimately resulting in higher affinity antibody being secreted? a) Somatic hypermutation. b) Retention of antigens on the surface of follicular dendritic cells for long periods. c) Preferential survival of higher affinity B cells. d) T helper cells interacting with those high affinity B cells that present antigen to them. CorrectWrong: a, b, c and d are correct.Your answer has been saved.

2

Which of the following statements are true? a) Blimp-1 is a transcriptional regulator that drives the plasma cell differentiation program. b) Plasma cells express chemokine receptors that direct their migration to appropriate locations in the body. c) Memory B cells do not require helper T cells to make an antibody response upon antigen stimulation. d) A network of transcriptional regulators controls whether an activated B cell in a germinal center will become a plasma cell or continue expansion, somatic hypermutation and selection for high affinity. CorrectWrong: a, b and d are true.Your answer has been saved.