Immunity: Chapter 06, B Cells and Humoral Immunity

Table of Contents

1. 6-1 Structure of Antibodies
2. 6-2 Structural Properties of Antibodies
3. 6-3 Effector Functions of Antibodies
4. 6-4 Monoclonal Antibodies
5. 6-5 Antibody-Based Methods: Radioimmunoassay and Hemagglutination
6. 6-6 Antibody-Based Methods: ELISA, Immunoblotting and FACS
7. 6-7 Antigen Receptors of B Lymphocytes
8. 6-8 B Cell Antigen Receptor Signaling and B Cell Coreceptors
9. 6-9 Early and T Cell-Independent Antibody Responses by B Cells
10. 6-10 Initiation of T Cell-Dependent Antibody Responses
11. 6-11 Hypermutation and Isotype Switching in the Germinal Center
12. 6-12 Selection and Differentiation of B Cells in the Germinal Center

6-11 Hypermutation and Isotype Switching in the Germinal Center

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

Which of the following statements are true? a) Interferon-γ induces memory B cell formation and prevents class switch recombination. b) Antigen is trapped in germinal centers by a non-lymphoid cell type called the follicular dendritic cell. c) Cytokines secreted by helper T cells direct class switch recombination to particular Ig classes. d) Long-lived plasma cells are generated primarily in T-independent antibody responses. CorrectWrong: b and c are true.Your answer has been saved.

2

With regard to activation-induced cytidine deaminase (AID), which of the following is/are correct: a) AID is necessary for somatic hypermutation of Ig genes leading to affinity maturation. b) AID regulates production of the secreted form of mRNA for Ig heavy chains. c) AID converts cytidine residues in DNA to uracil residues. d) AID is necessary for class switch recombination. CorrectWrong: a, c and d are correct.Your answer has been saved.