Immunity: Chapter 06, B Cells and Humoral Immunity

Table of Contents

1. 6-1 Structure of Antibodies
2. 6-2 Structural Properties of Antibodies
3. 6-3 Effector Functions of Antibodies
4. 6-4 Monoclonal Antibodies
5. 6-5 Antibody-Based Methods: Radioimmunoassay and Hemagglutination
6. 6-6 Antibody-Based Methods: ELISA, Immunoblotting and FACS
7. 6-7 Antigen Receptors of B Lymphocytes
8. 6-8 B Cell Antigen Receptor Signaling and B Cell Coreceptors
9. 6-9 Early and T Cell-Independent Antibody Responses by B Cells
10. 6-10 Initiation of T Cell-Dependent Antibody Responses
11. 6-11 Hypermutation and Isotype Switching in the Germinal Center
12. 6-12 Selection and Differentiation of B Cells in the Germinal Center

6-10 Initiation of T Cell-Dependent Antibody Responses

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

Which of the following statements are true? a) Before they recognize antigen, B cells and T cells are attracted to different regions of lymph nodes by different chemokines. b) Recognition of antigen by a B cell induces it to move from the T cell area into a follicle. c) B cells can present an antigen to helper T cells very efficiently if that antigen binds to their BCR. d) X-linked hyper-IgM syndrome is a genetic disease characterized by over-active helper T cells. CorrectWrong: a and c are true.Your answer has been saved.

2

Activation of follicular B cells by helper T cells during an immune response is promoted by which of the following: a) B7-2 expressed by the B cell. b) CD40L expressed by the helper T cell. c) ICOS ligand on the B cell. d) antigen presentation on MHC class I molecules. CorrectWrong: a b and c are correct.Your answer has been saved.