Immunity: Chapter 06, B Cells and Humoral Immunity

Table of Contents

1. 6-1 Structure of Antibodies
2. 6-2 Structural Properties of Antibodies
3. 6-3 Effector Functions of Antibodies
4. 6-4 Monoclonal Antibodies
5. 6-5 Antibody-Based Methods: Radioimmunoassay and Hemagglutination
6. 6-6 Antibody-Based Methods: ELISA, Immunoblotting and FACS
7. 6-7 Antigen Receptors of B Lymphocytes
8. 6-8 B Cell Antigen Receptor Signaling and B Cell Coreceptors
9. 6-9 Early and T Cell-Independent Antibody Responses by B Cells
10. 6-10 Initiation of T Cell-Dependent Antibody Responses
11. 6-11 Hypermutation and Isotype Switching in the Germinal Center
12. 6-12 Selection and Differentiation of B Cells in the Germinal Center

6-9 Early and T Cell-Independent Antibody Responses by B Cells

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

Which of the following statements are true? a) Follicular B cells only make T-independent antibody responses. b) A T-dependent IgG response is slower to appear than a T-independent IgM antibody response. c) Long-lived plasma cells are primarily generated in response to vaccines made of bacterial capsular polysaccharides. d) Natural antibodies are produced by B1 cells early in life, apparently without exposure to antigen. e) Many virus particles can induce rapid production of specific IgM antibodies, even in the absence of helper T cells. f) An antigen that contains Toll-like receptor ligands is typically a T-independent type 1 antigen for B cells. g) Defects in the protein kinase Btk lead to B cell immunodeficiency. h) T-independent antibodies are mostly IgM because viruses induce class switch to Ig μ heavy chain. CorrectWrong: b, d, e, f and g are true.Your answer has been saved.