Immunity: Chapter 06, B Cells and Humoral Immunity

Table of Contents

1. 6-1 Structure of Antibodies
2. 6-2 Structural Properties of Antibodies
3. 6-3 Effector Functions of Antibodies
4. 6-4 Monoclonal Antibodies
5. 6-5 Antibody-Based Methods: Radioimmunoassay and Hemagglutination
6. 6-6 Antibody-Based Methods: ELISA, Immunoblotting and FACS
7. 6-7 Antigen Receptors of B Lymphocytes
8. 6-8 B Cell Antigen Receptor Signaling and B Cell Coreceptors
9. 6-9 Early and T Cell-Independent Antibody Responses by B Cells
10. 6-10 Initiation of T Cell-Dependent Antibody Responses
11. 6-11 Hypermutation and Isotype Switching in the Germinal Center
12. 6-12 Selection and Differentiation of B Cells in the Germinal Center

6-8 B Cell Antigen Receptor Signaling and B Cell Coreceptors

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

Which of the following statements are true? a) The BCR Igα and Igβ chains contain ITAM sequences in their extracellular domains. b) BCR signaling is triggered by antigen-induced clustering of BCR molecules. c) Syk is an intracellular protein tyrosine kinase that plays a central role in BCR signaling. d) An adaptor molecule that plays an important role in BCR signaling is B cell linker protein (Blnk). e) The complement receptor on B cells can promote B cell activation. f) B cells express an inhibitory complement receptor that inhibits B cell activation. g) If a naïve B cell contacts antigen that is complexed with IgG antibodies then FcγRIIB on B cells dampens BCR signaling. h) Inhibitory receptors inhibit B cells by recruiting tyrosine kinases to the plasma membrane. CorrectWrong: b, c, d, e and g are true.Your answer has been saved.