Immunity: Chapter 06, B Cells and Humoral Immunity

Table of Contents

1. 6-1 Structure of Antibodies
2. 6-2 Structural Properties of Antibodies
3. 6-3 Effector Functions of Antibodies
4. 6-4 Monoclonal Antibodies
5. 6-5 Antibody-Based Methods: Radioimmunoassay and Hemagglutination
6. 6-6 Antibody-Based Methods: ELISA, Immunoblotting and FACS
7. 6-7 Antigen Receptors of B Lymphocytes
8. 6-8 B Cell Antigen Receptor Signaling and B Cell Coreceptors
9. 6-9 Early and T Cell-Independent Antibody Responses by B Cells
10. 6-10 Initiation of T Cell-Dependent Antibody Responses
11. 6-11 Hypermutation and Isotype Switching in the Germinal Center
12. 6-12 Selection and Differentiation of B Cells in the Germinal Center

6-1 Structure of Antibodies

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

Which of the following are structural features of antibodies? a) Each antibody has two heavy chains and two light chains. b) The complementary determining regions (CDRs) are found only in the heavy chain. c) Antigen binding specificity is contained in loops in the most N-terminal of the Ig domains. d) Proteases can be used to cleave antibody molecules into different fragments that either bind to antigen or are responsible for most of the effector functions of antibodies. CorrectWrong: a, c and d are correct.Your answer has been saved.

2

Which of the following statements are true? a) Cells of the immune system have receptors that recognize the part of antibodies contained in Fc fragments. b) The hinge in antibodies refers to a flexible region in the structure where the heavy chain and the light chain meet in their constant domains. c) The variability of antibodies is entirely encoded in the genome. d) The Fab fragment of antibodies contains the CH2 and CH3 regions of the heavy chain. CorrectWrong: a is true.Your answer has been saved.