5-14 Effector Functions of CD8 T Cells

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

Which of the following participate in the faster of the two cytotoxic pathways triggered on antigenic-peptide-MHC recognition by CD8 T cells?

Which of the following statements are true?

	a)	Activated CD8 T cells secrete cytokines typical of both T_H1 and T_H2 cells.
	b)	IFN-γ increases the effectiveness of antigen presentation to CD8 T cells.
	c)	CD8 T cells are primarily important in destroying pathogens that are harbored in the endocytic compartments inside cells.
	d)	CD8 T cells generally kill infected cells without destroying nearby healthy cells.
	e)	The formation of a specialized contact zone between a CD8 T cell and its target helps prevent damage to neighboring cells.
	f)	Cytotoxic T cells do not kill themselves on release of perforin and granzymes because granzymes are inactivated by cathepsins exposed on the CD8 T cell membrane at the site of release.
	g)	Perforin is closely related to the complement component C9.
	h)	Granzymes cleave caspase 3.
CorrectWrong: b d e g and h are trueYour answer has been saved.

In which of the following characteristics is the specialized contact zone (the immunological synapse) between CD8 T cells and their targets like the contact between a naïve T cell and a dendritic cell?

Immunity: Chapter 05 Activation and Effector Actions of T Cells

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5-14 Effector Functions of CD8 T Cells