Immunity: Chapter 05 Activation and Effector Actions of T Cells

Table of Contents

1. 5-1 Antigen Recognition by T Cells: Structure of the Receptor
2. 5-2 Antigen Recognition by T Cells: TCR Specificity and Coreceptors
3. 5-3 Signaling from the T Cell Receptor
4. 5-4 Regulation of TCR Signaling
5. 5-5 T Cell Signaling to the Nucleus and the Role of CD28
6. 5-6 Activation of Naïve T Cells in Secondary Lymphoid Tissue
7. 5-7 Clonal Expansion of Naïve T Cells in Secondary Lymphoid Tissue
8. 5-8 Costimulatory Signals in T Cell Proliferation and Survival
9. 5-9 Effector T Cell Differentiation
10. 5-10 The Polarization of TH1 and TH2 Cells
11. 5-11 The Functions of TH1 Cells
12. 5-12 The Functions of TH2 Cells
13. 5-13 The Functions of TFH Cells, TH17 Cells and Induced TREG Cells
14. 5-14 Effector Functions of CD8 T Cells
15. 5-15 T Cell Homeostasis and the Termination of Immune Responses
16. 5-16 T Cell Memory

5-13 The Functions of TFH Cells, TH17 Cells and Induced TREG Cells

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1	Which of the following molecules are expressed by TFH cells? a) CCR6 b) the IL-23 receptor c) RORγt d) CXCR5 CorrectWrong: d is correct.Your answer has been saved.

2

Which of the following statements are true? a) IL-17 promotes the production of neutrophils and their recruitment into tissues. b) Uptake of dead neutrophils induces IL-23 production by macrophages. c) TH1 cells promote the activation and survival of TH17 cells. d) TH17 cells migrate to sites of inflammation. e) iTREG cells prevent the differentiation of the other types of TH cells. f) TREG cells are characterized by the expression of the transcriptional activator FoxP3. g) IL-6 blocks the production of iTREG cells. h) iTREG cells are thought to prevent autoimmunity. CorrectWrong: a d f and g are trueYour answer has been saved.

3	Which of the following inhibit(s) the differentiation of TH17 cells? a) IL-12 b) IL-23 c) IL-4 d) IL-6 CorrectWrong: a and c are correct.Your answer has been saved.