Immunity: Chapter 05 Activation and Effector Actions of T Cells

Table of Contents

1. 5-1 Antigen Recognition by T Cells: Structure of the Receptor
2. 5-2 Antigen Recognition by T Cells: TCR Specificity and Coreceptors
3. 5-3 Signaling from the T Cell Receptor
4. 5-4 Regulation of TCR Signaling
5. 5-5 T Cell Signaling to the Nucleus and the Role of CD28
6. 5-6 Activation of Naïve T Cells in Secondary Lymphoid Tissue
7. 5-7 Clonal Expansion of Naïve T Cells in Secondary Lymphoid Tissue
8. 5-8 Costimulatory Signals in T Cell Proliferation and Survival
9. 5-9 Effector T Cell Differentiation
10. 5-10 The Polarization of TH1 and TH2 Cells
11. 5-11 The Functions of TH1 Cells
12. 5-12 The Functions of TH2 Cells
13. 5-13 The Functions of TFH Cells, TH17 Cells and Induced TREG Cells
14. 5-14 Effector Functions of CD8 T Cells
15. 5-15 T Cell Homeostasis and the Termination of Immune Responses
16. 5-16 T Cell Memory

5-11 The Functions of TH1 Cells

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1	Which of the following cytokines accounts for most of the effects of TH1 cell activation? a) TNF b) IFN-γ c) IL-12 d) IL-6 CorrectWrong: b is correct.Your answer has been saved.

2

Which of the following statements are true? a) TH1 cells are recruited primarily to sites of inflammation b) TH1 cells are often found in inflammatory sites with CD8 T cells and NK cells. c) Antibodies induced by TH1 cells acting on B cells are effective activators of complement. d) NK cells reinforce the polarization of TH1 cells by releasing TNF. e) Deficiencies in IFN-γ or IFN-γ signaling lead to increased susceptibility to infection with intracellular bacteria. f) Antibodies induced by TH1 cells acting on B cells enhance phagocytosis by macrophages. g) IL-2 released by NK cells helps to polarize TH1 cells in lymph nodes. h) IFN-γ upregulates Fc receptors and complement receptors that promote phagocytosis by macrophages. CorrectWrong: a b c e f and h are trueYour answer has been saved.

3

Which of the following are consequences of macrophage activation by TH1 cells? a) Increased phagocytosis. b) Increased presentation of antigens on MHC molecules. c) Increased CD8 T cell cytotoxicity. d) Increased destruction of intracellular bacteria. e) Recruitment of TipDCs. CorrectWrong: a, b, d and e are correct.Your answer has been saved.