Immunity: Chapter 05 Activation and Effector Actions of T Cells

Table of Contents

1. 5-1 Antigen Recognition by T Cells: Structure of the Receptor
2. 5-2 Antigen Recognition by T Cells: TCR Specificity and Coreceptors
3. 5-3 Signaling from the T Cell Receptor
4. 5-4 Regulation of TCR Signaling
5. 5-5 T Cell Signaling to the Nucleus and the Role of CD28
6. 5-6 Activation of Naïve T Cells in Secondary Lymphoid Tissue
7. 5-7 Clonal Expansion of Naïve T Cells in Secondary Lymphoid Tissue
8. 5-8 Costimulatory Signals in T Cell Proliferation and Survival
9. 5-9 Effector T Cell Differentiation
10. 5-10 The Polarization of TH1 and TH2 Cells
11. 5-11 The Functions of TH1 Cells
12. 5-12 The Functions of TH2 Cells
13. 5-13 The Functions of TFH Cells, TH17 Cells and Induced TREG Cells
14. 5-14 Effector Functions of CD8 T Cells
15. 5-15 T Cell Homeostasis and the Termination of Immune Responses
16. 5-16 T Cell Memory

5-10 The Polarization of TH1 and TH2 Cells

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1	Which of the following contribute(s) to the establishment of the TH2 cell fate? a) GATA-3 b) T-bet c) STAT4 d) IL-4 e) IFN-γR CorrectWrong: a and d are correct.Your answer has been saved.

2

Which of the following statements are true? a) NFAT contributes to the differentiation of both TH1 and TH2 cells. b) T-bet activates transcription of the gene encoding T-bet. c) Signaling through the IFN-γ receptor suppresses expression of IL-4. d) TH1 cells express chemokine receptors responsive to chemokines induced by IFN-g. e) IL-4 promotes the expression of GATA-3. f) The IL-15 receptor is required for the survival of CD4 T cells. g) GATA-3 acts to modify chromatin structure in the region containing TH2 cytokine genes. h) IL-12 is secreted by dendritic cells activated by IFN-γ or through TLRs. CorrectWrong: a c d e f and g are true.Your answer has been saved.

3	Which of the following contribute(s) to the differentiation of CD8 T cells? a) GATA-3 b) eomesodermin c) T-bet d) ICOS CorrectWrong: b and c are correct.Your answer has been saved.