Immunity: Chapter 05 Activation and Effector Actions of T Cells

Table of Contents

1. 5-1 Antigen Recognition by T Cells: Structure of the Receptor
2. 5-2 Antigen Recognition by T Cells: TCR Specificity and Coreceptors
3. 5-3 Signaling from the T Cell Receptor
4. 5-4 Regulation of TCR Signaling
5. 5-5 T Cell Signaling to the Nucleus and the Role of CD28
6. 5-6 Activation of Naïve T Cells in Secondary Lymphoid Tissue
7. 5-7 Clonal Expansion of Naïve T Cells in Secondary Lymphoid Tissue
8. 5-8 Costimulatory Signals in T Cell Proliferation and Survival
9. 5-9 Effector T Cell Differentiation
10. 5-10 The Polarization of TH1 and TH2 Cells
11. 5-11 The Functions of TH1 Cells
12. 5-12 The Functions of TH2 Cells
13. 5-13 The Functions of TFH Cells, TH17 Cells and Induced TREG Cells
14. 5-14 Effector Functions of CD8 T Cells
15. 5-15 T Cell Homeostasis and the Termination of Immune Responses
16. 5-16 T Cell Memory

5-6 Activation of Naïve T Cells in Secondary Lymphoid Tissue

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

Many molecules on the surface of T cells play a part in the cell-cell interactions that mediate migration and homing. Which of the following T cell surface molecules specifically direct(s) homing to lymph nodes? a) LFA-1 b) L-selectin c) CCR7 d) CD2 CorrectWrong: b and c are correct.Your answer has been saved.

2

Which of the following statements are true? a) Dendritic cells that have matured in the periphery can induce a state of non-responsiveness, and thus tolerance to the presented antigen, in naïve T cells. b) Dendritic cells that have matured in the periphery are essential for the activation of naïve T cells. c) Soluble antigens entering the lymph node in the afferent lymph can activate immature dendritic cells that are resident in the T cell areas of the lymph node. d) Productive activation of T cells occurs within minutes of the introduction of antigen in the peripheral tissues. CorrectWrong: a, b, and c are true.Your answer has been saved.