Immunity: Chapter 05 Activation and Effector Actions of T Cells

Table of Contents

1. 5-1 Antigen Recognition by T Cells: Structure of the Receptor
2. 5-2 Antigen Recognition by T Cells: TCR Specificity and Coreceptors
3. 5-3 Signaling from the T Cell Receptor
4. 5-4 Regulation of TCR Signaling
5. 5-5 T Cell Signaling to the Nucleus and the Role of CD28
6. 5-6 Activation of Naïve T Cells in Secondary Lymphoid Tissue
7. 5-7 Clonal Expansion of Naïve T Cells in Secondary Lymphoid Tissue
8. 5-8 Costimulatory Signals in T Cell Proliferation and Survival
9. 5-9 Effector T Cell Differentiation
10. 5-10 The Polarization of TH1 and TH2 Cells
11. 5-11 The Functions of TH1 Cells
12. 5-12 The Functions of TH2 Cells
13. 5-13 The Functions of TFH Cells, TH17 Cells and Induced TREG Cells
14. 5-14 Effector Functions of CD8 T Cells
15. 5-15 T Cell Homeostasis and the Termination of Immune Responses
16. 5-16 T Cell Memory

5-1 Antigen Recognition by T Cells: Structure of the Receptor

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1	Which of the following chains of the T cell antigen receptor contain(s) immunoreceptor tyrosine-based activating motifs (ITAMS)? a) the ζ chains b) the α chain c) the β chain d) the ε chain CorrectWrong: a and d are correct.Your answer has been saved.

2

Which of the following statements are true? a) All antigen receptors of T cells contain variable α and β chains. b) The complementarity-determining regions of the T cell receptor are the regions that recognize antigen. c) Antigen is recognized by the T cell receptor through three hypervariable regions in each of the two receptor chains and that together form the antigen-binding site. d) Each receptor chain contains two constant regions as well as the variable antigen-binding region. e) The diversity of T cell receptors is due in part to the existence of many different V gene segments in the genome. f) The variable region of the α chain of the T cell receptor is encoded by V-, D- and J-segment DNA. g) V, D and J segments are combined in different ways in different T lymphocytes to generate DNA sequences encoding V regions with distinct specificities for antigen. Correct:Wrong: b, c, e and g are trueYour answer has been saved.

3	The third hypervariable region of the T cell receptor (CDR3) is formed from the region encoded by: a) the V segment. b) the D segment. c) the J segment. d) the D and J segments together. CorrectWrong: c and d are correct.Your answer has been saved.