Immunity: Chapter 04, Adaptive Immunity and the Detection of Infection by T Lymphocytes

Table of Contents

1. 4-1 Dendritic Cells in the Induction of Adaptive Immunity
2. 4-2 The Structure and Function of MHC Molecules
3. 4-3 The MHC and Polymorphism of MHC Molecules
4. 4-4 Non-Classical MHC Class I Molecules
5. 4-5 Peptide Binding by MHC Molecules
6. 4-6 Antigen Presentation by Classical MHC Class I Molecules
7. 4-7 Antigen Presentation by MHC Class II Molecules
8. 4-8 Regulation of Antigen Presentation
9. 4-9 Specialized Features of Antigen Presentation by Dendritic Cells

4-8 Regulation of Antigen Presentation

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

Which of the following are thought to be the major consequences of the inclusion in the proteasome of the specialized subunits of the immunoproteasome? a) More rapid degradation of proteins. b) Production of a broader range of peptides. c) More efficient transport of peptides through the TAP transporter. d) More efficient activation of CD4 helper T cells. CorrectWrong: b and c are correct.Your answer has been saved.

2

Which of the following statements are true? a) CIITA activates transcription of the genes encoding MHC class II α and β chains, the invariant chain, DM and DO. b) Macrophages constitutively express very high levels of surface MHC class II molecules. c) The upregulation of lysosomal proteases by interferon-g increases the cell-surface expression of MHC class II molecules. d) Different elements of the promoter for the gene encoding CIITA are active in different immune-cell types and account for different patterns of expression of MHC class II molecules. CorrectWrong: a and d are true.Your answer has been saved.