Immunity: Chapter 04, Adaptive Immunity and the Detection of Infection by T Lymphocytes

Table of Contents

1. 4-1 Dendritic Cells in the Induction of Adaptive Immunity
2. 4-2 The Structure and Function of MHC Molecules
3. 4-3 The MHC and Polymorphism of MHC Molecules
4. 4-4 Non-Classical MHC Class I Molecules
5. 4-5 Peptide Binding by MHC Molecules
6. 4-6 Antigen Presentation by Classical MHC Class I Molecules
7. 4-7 Antigen Presentation by MHC Class II Molecules
8. 4-8 Regulation of Antigen Presentation
9. 4-9 Specialized Features of Antigen Presentation by Dendritic Cells

4-7 Antigen Presentation by MHC Class II Molecules

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

Which of the following is/are among the function(s) of the invariant chain (I chain, or Ii) that associates with MHC class II molecules in the endoplasmic reticulum? a) Promotion of the formation of MHC class II molecule heterodimers. b) Protection of the peptide-binding groove of MHC class II molecules in the endoplasmic reticulum. c) Activation of cathepsins. d) Targeting of newly synthesized MHC class II molecules to the membranes of endosomal-lysosomal vesicles. CorrectWrong: b and d are correct.Your answer has been saved.

2

Which of the following statements are true? a) The first chaperone molecule on the peptide-loading pathway of MHC class II molecules is calnexin. b) Class II-associated invariant chain peptide (CLIP) is the degradation fragment of the invariant chain that protects the peptide-binding groove of the MHC class II molecule. c) The non-classical MHC class II molecule DM displaces the invariant chain in order to bind the classical MHC class II molecule as it progresses through the endosomal-lysosomal system. d) Cathepsins activated by the low pH of the endosomal-lysosomal system degrade both antigenic peptides and the invariant chain. CorrectWrong: a, b and d are true.Your answer has been saved.