Immunity: Chapter 04, Adaptive Immunity and the Detection of Infection by T Lymphocytes

Which of the following components of the MHC class I peptide processing and loading machinery hold(s) the MHC class I alpha chain in association with the transporter through which peptides enter the endoplasmic reticulum lumen from the cytoplasm?

	a)	calnexin
	b)	calmodulin
	c)	ERp57
	d)	tapasin
CorrectWrong: d is correct.Your answer has been saved.

Which of the following statements are true?

	a)	The transporter associated with antigen processing (TAP) is encoded in the MHC.
	b)	ERp57 is an aminopeptidase that trims peptides generated by the proteasome.
	c)	The proteasome is specialized to degrade protein products of infectious agents for binding to both MHC class I and MHC class II molecules.
	d)	Peptides from cytosolic proteins must be transported into the lumen of the endoplasmic reticulum (ER) in order to bind MHC class I molecules because the extracellular domains of these molecules are inserted into the ER lumen during synthesis and are never exposed to the cytosol.
CorrectWrong: a and d are true.Your answer has been saved.