Immunity: Chapter 04, Adaptive Immunity and the Detection of Infection by T Lymphocytes

Table of Contents

1. 4-1 Dendritic Cells in the Induction of Adaptive Immunity
2. 4-2 The Structure and Function of MHC Molecules
3. 4-3 The MHC and Polymorphism of MHC Molecules
4. 4-4 Non-Classical MHC Class I Molecules
5. 4-5 Peptide Binding by MHC Molecules
6. 4-6 Antigen Presentation by Classical MHC Class I Molecules
7. 4-7 Antigen Presentation by MHC Class II Molecules
8. 4-8 Regulation of Antigen Presentation
9. 4-9 Specialized Features of Antigen Presentation by Dendritic Cells

4-5 Peptide Binding by MHC Molecules

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

Which of the following is/are characteristic of peptide binding to MHC class II molecules? a) Preference for peptides 8-10 amino-acid residues in length. b) Invariant contacts with the amino and carboxyl ends of peptides. c) Contacts between the backbone of the peptide and the floor of the peptide-binding groove. CorrectWrong: c is correct.Your answer has been saved.

2

Which of the following statements are true? a) Anchor residues are the amino-acid residues in peptides that make invariant contacts with the peptide-binding grooves of MHC molecules. b) The open-ended peptide-binding groove of MHC class II molecules helps allow peptides to bind before they are degraded by endosomal-lysosomal enzymes. c) Variable pockets in the peptide-binding groove determine the specific peptides bound by both MHC class I and MHC class II molecules. d) The peptide-binding groove of MHC class I molecules is closed at both ends. CorrectWrong: b, c and d are true.Your answer has been saved.