Immunity: Chapter 04, Adaptive Immunity and the Detection of Infection by T Lymphocytes

Table of Contents

1. 4-1 Dendritic Cells in the Induction of Adaptive Immunity
2. 4-2 The Structure and Function of MHC Molecules
3. 4-3 The MHC and Polymorphism of MHC Molecules
4. 4-4 Non-Classical MHC Class I Molecules
5. 4-5 Peptide Binding by MHC Molecules
6. 4-6 Antigen Presentation by Classical MHC Class I Molecules
7. 4-7 Antigen Presentation by MHC Class II Molecules
8. 4-8 Regulation of Antigen Presentation
9. 4-9 Specialized Features of Antigen Presentation by Dendritic Cells

4-2 The Structure and Function of MHC Molecules

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

Which of the following features are common to both MHC class I and MHC class II molecules? a) They are composed of two nonidentical transmembrane chains. b) The membrane-distal domains of the two chains of the MHC protein form a groove in which peptides bind. c) They do not fold stably in the absence of bound peptide. d) They are expressed on virtually all body cells. CorrectWrong: b and c are correct.Your answer has been saved.

2

Which of the following statements are true? a) MHC molecules bind only peptides generated from infectious agents. b) MHC class I molecules are specialized to present peptides generated in the cytoplasm where viral proteins are synthesized, and therefore do not present peptides from bacterial proteins. c) MHC class II molecules can present peptides generated from any infectious agent internalized by phagocytes. d) Only the α chain of the MHC class I molecule is synthesized in the major histocompatibility complex. CorrectWrong: c and d are true.Your answer has been saved.