Immunity: Chapter 03, Innate Immunity

Table of Contents

1. 3-1 Barriers to Infection at the Epithelium
2. 3-2 Innate Recognition by Soluble Collectins and Ficolins
3. 3-3 Overview of the Complement System
4. 3-4 Activation of the Complement Cascade
5. 3-5 Complement Effector Actions and Receptors
6. 3-6 Regulation of Complement and Evasion by Microbes
7. 3-7 Recognition of Microbes by Phagocytes
8. 3-8 Mechanisms of Phagocytosis
9. 3-9 Destructive Mechanisms of Phagocytes
10. 3-10 The Toll-Like Receptor Family of Innate Immune Receptors
11. 3-11 Toll-Like Receptor Signaling to Cytokine Production
12. 3-12 Intracellular Sensors of Bacterial Peptidoglycan Components
13. 3-13 Inflammation: Initiation of an Inflammatory Response
14. 3-14 Inflammation: Recruitment of Immune Cells
15. 3-15 Inflammation: Regulation and Systemic Effects
16. 3-16 Innate Defense Against Viruses: Interferon
17. 3-17 Inhibition of Virus Replication by Interferon
18. 3-18 Innate Defense Against Viruses: Induction of Apoptosis
19. 3-19 Intracellular Defenses Targeting Viral Nucleic Acid

3-19 Intracellular Defenses Targeting Viral Nucleic Acid

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1	APOBEC3G inhibits retroviral infection by: a) preventing the viral coat proteins from forming capsids. b) cleaving the viral RNA. c) introducing mutations into viral RNA. d) deamination of cytidines in viral RNA. CorrectWrong: c and d are correct.Your answer has been saved.

2

Which of the following statements are true? a) Small interfering RNAs (siRNAs) are targeted to viral RNA or mRNA by Dicer. b) siRNAs are small cleavage fragments of double-stranded RNAs. c) The RISC complex is targeted to RNAs with homology to siRNAs. d) RNA interference is a pathway whereby double-stranded RNAs are recognized, leading to their destruction and the destruction of homologous RNAs. CorrectWrong: b c and d are true.Your answer has been saved.