Immunity: Chapter 03, Innate Immunity

Table of Contents

1. 3-1 Barriers to Infection at the Epithelium
2. 3-2 Innate Recognition by Soluble Collectins and Ficolins
3. 3-3 Overview of the Complement System
4. 3-4 Activation of the Complement Cascade
5. 3-5 Complement Effector Actions and Receptors
6. 3-6 Regulation of Complement and Evasion by Microbes
7. 3-7 Recognition of Microbes by Phagocytes
8. 3-8 Mechanisms of Phagocytosis
9. 3-9 Destructive Mechanisms of Phagocytes
10. 3-10 The Toll-Like Receptor Family of Innate Immune Receptors
11. 3-11 Toll-Like Receptor Signaling to Cytokine Production
12. 3-12 Intracellular Sensors of Bacterial Peptidoglycan Components
13. 3-13 Inflammation: Initiation of an Inflammatory Response
14. 3-14 Inflammation: Recruitment of Immune Cells
15. 3-15 Inflammation: Regulation and Systemic Effects
16. 3-16 Innate Defense Against Viruses: Interferon
17. 3-17 Inhibition of Virus Replication by Interferon
18. 3-18 Innate Defense Against Viruses: Induction of Apoptosis
19. 3-19 Intracellular Defenses Targeting Viral Nucleic Acid

3-16 Innate Defense Against Viruses: Interferon

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1	Interferon-α is produced in response to signaling through: a) TLR3. b) MyD88. c) TLR7. d) TLR9. CorrectWrong: b, c and d are correct.Your answer has been saved.

2

Which of the following statements are true? a) Interferon-α and interferon-β are both type 2 interferons. b) RIG-I and Mda5 recognize double-stranded RNA. c) RIG-I and Mda5 activate transcription of the interferon-β gene. d) Signaling through the interferon receptor activates transcription of the interferon-α gene. e) STAT1 is an essential component of the signaling pathway from interferon receptors. CorrectWrong: b c d and e are true.Your answer has been saved.

3	Which of the following signaling molecules contribute(s) to the specialized role of plasmacytoid dendritic cells in interferon production? a) TLR3. b) TLR7. c) TLR9. d) TRIF. e) IRF-7. CorrectWrong: b, c and e are correct.Your answer has been saved.