Immunity: Chapter 03, Innate Immunity

Factors that contribute to the switch from an inflammatory response dominated by neutrophils to one dominated by monocytes are:

	a)	production of IL-6.
	b)	production of acute phase proteins.
	c)	production of the CC chemokines MCP-1 and MCP-3.
	d)	production of PGE2.
	e)	release of IL-6 receptors from neutrophils.
CorrectWrong: a, c, and e are correct.Your answer has been saved.

Which of the following statements are true?

	a)	Endothelial cells produce CC chemokines in response to IL-6.
	b)	Endothelial cells do not express IL-6 receptors.
	c)	TNF acts on the liver to induce the acute phase response.
	d)	IL-6 and IL-1 act on the hypothalamus to induce fever.
CorrectWrong: a, b and d are true.Your answer has been saved.

Inflammatory responses are amplified by proinflammatory cytokines released by macrophages and that induce the production of more proinflammatory cytokines from neighboring cells. Which of the following act to downregulate inflammatory responses so that they are terminated when infection is cleared:

	a)	production of soluble IL-1 receptors.
	b)	shedding of TNF receptors.
	c)	inhibition of caspase 1 which is required to cleave the inactive precursor of IL-1.
	d)	production of an antagonist of IL-1.
	e)	production of IL-10 and TGF-β.
CorrectWrong: b, d and e are correct.Your answer has been saved.