Immunity: Chapter 03, Innate Immunity

Table of Contents

1. 3-1 Barriers to Infection at the Epithelium
2. 3-2 Innate Recognition by Soluble Collectins and Ficolins
3. 3-3 Overview of the Complement System
4. 3-4 Activation of the Complement Cascade
5. 3-5 Complement Effector Actions and Receptors
6. 3-6 Regulation of Complement and Evasion by Microbes
7. 3-7 Recognition of Microbes by Phagocytes
8. 3-8 Mechanisms of Phagocytosis
9. 3-9 Destructive Mechanisms of Phagocytes
10. 3-10 The Toll-Like Receptor Family of Innate Immune Receptors
11. 3-11 Toll-Like Receptor Signaling to Cytokine Production
12. 3-12 Intracellular Sensors of Bacterial Peptidoglycan Components
13. 3-13 Inflammation: Initiation of an Inflammatory Response
14. 3-14 Inflammation: Recruitment of Immune Cells
15. 3-15 Inflammation: Regulation and Systemic Effects
16. 3-16 Innate Defense Against Viruses: Interferon
17. 3-17 Inhibition of Virus Replication by Interferon
18. 3-18 Innate Defense Against Viruses: Induction of Apoptosis
19. 3-19 Intracellular Defenses Targeting Viral Nucleic Acid

3-14 Inflammation: Recruitment of Immune Cells

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1	Which of the following molecules mediates transmigration of leukocytes between endothelial cells? a) VCAM b) E-selectin c) P-selectin d) CD31 CorrectWrong: d is correct.Your answer has been saved.

2

Which of the following statements are true? a) The inflammatory cytokines TNF and IL-1 promote migration of neutrophils to sites of infection by inducing the production of the chemokine IL-8. b) Proteoglycans on endothelial cells contribute to recruitment of phagocytes by binding to selectins. c) E-selectin is rapidly released from storage vesicles in endothelial cells in response to inflammatory cytokines produced by macrophages. d) Neutrophils are attracted to sites of infection in tissues by C5a produced through activation of the complement cascade at bacterial cell surfaces. Correct.Wrong: a and d are true.Your answer has been saved.

3	Fucosylation enzymes contribute to immune cell recruitment to sites of infection by: a) cleaving inactive precursors of inflammatory cytokines b) cleaving N-formylated peptides from bacterial proteins c) synthesizing selectin ligands CorrectWrong: c is correct.Your answer has been saved.