Immunity: Chapter 03, Innate Immunity

Table of Contents

1. 3-1 Barriers to Infection at the Epithelium
2. 3-2 Innate Recognition by Soluble Collectins and Ficolins
3. 3-3 Overview of the Complement System
4. 3-4 Activation of the Complement Cascade
5. 3-5 Complement Effector Actions and Receptors
6. 3-6 Regulation of Complement and Evasion by Microbes
7. 3-7 Recognition of Microbes by Phagocytes
8. 3-8 Mechanisms of Phagocytosis
9. 3-9 Destructive Mechanisms of Phagocytes
10. 3-10 The Toll-Like Receptor Family of Innate Immune Receptors
11. 3-11 Toll-Like Receptor Signaling to Cytokine Production
12. 3-12 Intracellular Sensors of Bacterial Peptidoglycan Components
13. 3-13 Inflammation: Initiation of an Inflammatory Response
14. 3-14 Inflammation: Recruitment of Immune Cells
15. 3-15 Inflammation: Regulation and Systemic Effects
16. 3-16 Innate Defense Against Viruses: Interferon
17. 3-17 Inhibition of Virus Replication by Interferon
18. 3-18 Innate Defense Against Viruses: Induction of Apoptosis
19. 3-19 Intracellular Defenses Targeting Viral Nucleic Acid

3-13 Inflammation: Initiation of an Inflammatory Response

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1	Which of the following consequences of inflammatory responses are directly due to the activation of endothelium? a) Recruitment of phagocytes. b) Activation of NK cells. c) Activation of the kinin and coagulation cascades. d) Edema. CorrectWrong: a, c and d are correct.Your answer has been saved.

2

Which of the following statements are true? a) Leukotrienes and prostaglandins are synthesized from arachidonic acid released from cell membranes by phospholipase A2 (PLA2). b) Aspirin is a non-steroidal antiinflammatory drug. c) Leukotrienes act faster than prostaglandins. d) Prostaglandins are synthesized from arachidonic acid by 5-lipoxygenase. CorrectWrong: a and b are true.Your answer has been saved.

3	Non-steroidal antiinflammatory drugs act by: a) blocking the response of endothelial cells to inflammatory mediators b) inhibiting cyclooxygenases c) preventing prostaglandin biosynthesis d) preventing histamine release by mast cells CorrectWrong: b and c are correct.Your answer has been saved.