Immunity: Chapter 03, Innate Immunity

Table of Contents

1. 3-1 Barriers to Infection at the Epithelium
2. 3-2 Innate Recognition by Soluble Collectins and Ficolins
3. 3-3 Overview of the Complement System
4. 3-4 Activation of the Complement Cascade
5. 3-5 Complement Effector Actions and Receptors
6. 3-6 Regulation of Complement and Evasion by Microbes
7. 3-7 Recognition of Microbes by Phagocytes
8. 3-8 Mechanisms of Phagocytosis
9. 3-9 Destructive Mechanisms of Phagocytes
10. 3-10 The Toll-Like Receptor Family of Innate Immune Receptors
11. 3-11 Toll-Like Receptor Signaling to Cytokine Production
12. 3-12 Intracellular Sensors of Bacterial Peptidoglycan Components
13. 3-13 Inflammation: Initiation of an Inflammatory Response
14. 3-14 Inflammation: Recruitment of Immune Cells
15. 3-15 Inflammation: Regulation and Systemic Effects
16. 3-16 Innate Defense Against Viruses: Interferon
17. 3-17 Inhibition of Virus Replication by Interferon
18. 3-18 Innate Defense Against Viruses: Induction of Apoptosis
19. 3-19 Intracellular Defenses Targeting Viral Nucleic Acid

3-10 The Toll-Like Receptor Family of Innate Immune Receptors

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1	Lipopolysaccharide (LPS), a major component of the cell wall of Gram-negative bacteria, is the principal ligand for: a) TLR2. b) TLR3. c) TLR4. d) TLR5. CorrectWrong: c is correct.Your answer has been saved.

2	The TLRs that are localized to internal membrane-bounded compartments such as the phagosme are those that recognize: a) lipoproteins and lipoteichoic acid. b) double-stranded RNA (dsRNA). c) CpG-containing DNA. d) flagellin. CorrectWrong: b and c are correct.Your answer has been saved.

3

Which of the following statements are true? a) CD14 promotes binding of LPS by TLRs. b) CD14 promotes binding of lipoteichoic acid by TLRs. c) Dectin-1 promotes recognition of fungal cell wall components by TLRs. d) Unmethylated CG dinucleotides are a distinguishing feature of vertebrate DNA. CorrectWrong: a, b and c are true.Your answer has been saved.