Immunity: Chapter 03, Innate Immunity

Table of Contents

1. 3-1 Barriers to Infection at the Epithelium
2. 3-2 Innate Recognition by Soluble Collectins and Ficolins
3. 3-3 Overview of the Complement System
4. 3-4 Activation of the Complement Cascade
5. 3-5 Complement Effector Actions and Receptors
6. 3-6 Regulation of Complement and Evasion by Microbes
7. 3-7 Recognition of Microbes by Phagocytes
8. 3-8 Mechanisms of Phagocytosis
9. 3-9 Destructive Mechanisms of Phagocytes
10. 3-10 The Toll-Like Receptor Family of Innate Immune Receptors
11. 3-11 Toll-Like Receptor Signaling to Cytokine Production
12. 3-12 Intracellular Sensors of Bacterial Peptidoglycan Components
13. 3-13 Inflammation: Initiation of an Inflammatory Response
14. 3-14 Inflammation: Recruitment of Immune Cells
15. 3-15 Inflammation: Regulation and Systemic Effects
16. 3-16 Innate Defense Against Viruses: Interferon
17. 3-17 Inhibition of Virus Replication by Interferon
18. 3-18 Innate Defense Against Viruses: Induction of Apoptosis
19. 3-19 Intracellular Defenses Targeting Viral Nucleic Acid

3-9 Destructive Mechanisms of Phagocytes

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1	Which of the following are features of iNOS and not of NADPH oxidase? a) Induction by transcriptional activation b) Participation in the release of active proteases stored in the primary granules of neutrophils c) Induction by interferon- γ CorrectWrong: a is correct.Your answer has been saved.

2

Which of the following statements are true? a) Neutrophils store pre-formed microbicidal components in their primary and secondary granules. b) NADPH oxidase is activated more rapidly than iNOS on stimulation of macrophages through phagocytic receptors. c) Granulomas containing live bacteria are a typical consequence of the microbicidal actions of phagocytes. d) iNOS and NADPH oxidase kill micribes by producing reactive oxygen and nitrogen intermediates that oxidate, chlorinate and nitrosylate microbial components. CorrectWrong: a, b and d are true.Your answer has been saved.