Immunity: Chapter 03, Innate Immunity

Table of Contents

1. 3-1 Barriers to Infection at the Epithelium
2. 3-2 Innate Recognition by Soluble Collectins and Ficolins
3. 3-3 Overview of the Complement System
4. 3-4 Activation of the Complement Cascade
5. 3-5 Complement Effector Actions and Receptors
6. 3-6 Regulation of Complement and Evasion by Microbes
7. 3-7 Recognition of Microbes by Phagocytes
8. 3-8 Mechanisms of Phagocytosis
9. 3-9 Destructive Mechanisms of Phagocytes
10. 3-10 The Toll-Like Receptor Family of Innate Immune Receptors
11. 3-11 Toll-Like Receptor Signaling to Cytokine Production
12. 3-12 Intracellular Sensors of Bacterial Peptidoglycan Components
13. 3-13 Inflammation: Initiation of an Inflammatory Response
14. 3-14 Inflammation: Recruitment of Immune Cells
15. 3-15 Inflammation: Regulation and Systemic Effects
16. 3-16 Innate Defense Against Viruses: Interferon
17. 3-17 Inhibition of Virus Replication by Interferon
18. 3-18 Innate Defense Against Viruses: Induction of Apoptosis
19. 3-19 Intracellular Defenses Targeting Viral Nucleic Acid

3-8 Mechanisms of Phagocytosis

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

Phagocytosis of particles that is induced primarily through engagement of the complement receptor CR3 by iC3b is characterized by: a) rapid engulfment of the particle through a process called zippering b) dependence on the small Rho-family GTPases Rac and Cdc42 c) slow fusion of phagosomes to lysosomes d) dependence on the small GTPase Rho CorrectWrong: c and d are correct.Your answer has been saved.

2

Which of the following statements are true? a) Uninfected apoptotic cells are opsonized and recognized by complement receptors. b) Uninfected apoptotic cells induce the production of antiinflammatory cytokines. c) Uninfected apoptotic cells are recognized by receptors that inhibit phagocytosis. d) Uninfected apoptotic cells are destroyed by autophagy. CorrectWrong: a and b are true.Your answer has been saved.