Immunity: Chapter 03, Innate Immunity

Table of Contents

1. 3-1 Barriers to Infection at the Epithelium
2. 3-2 Innate Recognition by Soluble Collectins and Ficolins
3. 3-3 Overview of the Complement System
4. 3-4 Activation of the Complement Cascade
5. 3-5 Complement Effector Actions and Receptors
6. 3-6 Regulation of Complement and Evasion by Microbes
7. 3-7 Recognition of Microbes by Phagocytes
8. 3-8 Mechanisms of Phagocytosis
9. 3-9 Destructive Mechanisms of Phagocytes
10. 3-10 The Toll-Like Receptor Family of Innate Immune Receptors
11. 3-11 Toll-Like Receptor Signaling to Cytokine Production
12. 3-12 Intracellular Sensors of Bacterial Peptidoglycan Components
13. 3-13 Inflammation: Initiation of an Inflammatory Response
14. 3-14 Inflammation: Recruitment of Immune Cells
15. 3-15 Inflammation: Regulation and Systemic Effects
16. 3-16 Innate Defense Against Viruses: Interferon
17. 3-17 Inhibition of Virus Replication by Interferon
18. 3-18 Innate Defense Against Viruses: Induction of Apoptosis
19. 3-19 Intracellular Defenses Targeting Viral Nucleic Acid

3-6 Regulation of Complement and Evasion by Microbes

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1	Which of the following proteins induce(s) dissociation of membrane-bound C3 convertases thereby inactivating them? a) factor H b) C1 inhibitor c) C4-binding protein (C4bp) d) complement receptor 1 (CR1) e) decay-accelerating factor (DAF) CorrectWrong: d and e are correct.Your answer has been saved.

2

Which of the following statements are true? a) CR1 and factor H recruit factor I to the membrane to inactivate bound C3b. b) Membrane cofactor of proteolysis induces dissociation of convertases. c) Inactivation of C3b prevents both amplification of the complement cascade and initiation of the late events of complement activation. d) Protectin (CD59) binds to C9 preventing it from assembling to form a pore. CorrectWrong: a and c are true.Your answer has been saved.