Immunity: Chapter 03, Innate Immunity

Table of Contents

1. 3-1 Barriers to Infection at the Epithelium
2. 3-2 Innate Recognition by Soluble Collectins and Ficolins
3. 3-3 Overview of the Complement System
4. 3-4 Activation of the Complement Cascade
5. 3-5 Complement Effector Actions and Receptors
6. 3-6 Regulation of Complement and Evasion by Microbes
7. 3-7 Recognition of Microbes by Phagocytes
8. 3-8 Mechanisms of Phagocytosis
9. 3-9 Destructive Mechanisms of Phagocytes
10. 3-10 The Toll-Like Receptor Family of Innate Immune Receptors
11. 3-11 Toll-Like Receptor Signaling to Cytokine Production
12. 3-12 Intracellular Sensors of Bacterial Peptidoglycan Components
13. 3-13 Inflammation: Initiation of an Inflammatory Response
14. 3-14 Inflammation: Recruitment of Immune Cells
15. 3-15 Inflammation: Regulation and Systemic Effects
16. 3-16 Innate Defense Against Viruses: Interferon
17. 3-17 Inhibition of Virus Replication by Interferon
18. 3-18 Innate Defense Against Viruses: Induction of Apoptosis
19. 3-19 Intracellular Defenses Targeting Viral Nucleic Acid

3-5 Complement Effector Actions and Receptors

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1	Which of the following complement components act/acts as an opsonin? a) C3a b) C5a c) C3b d) C6 CorrectWrong: c is correct.Your answer has been saved.

2

Which of the following statements are true? a) The production of active fragments of C5 requires binding of C5 to the cell membrane. b) The production of active fragments of C5 requires binding of C5 to C3b. c) The production of active fragments of C5 requires cleavage by C3 convertase. d) The production of active fragments of C5 requires assembly of C6, C7 and C8. e) The membrane-attack complex contains multiple copies of C7. f) Factor I cleaves and inactivates C3b. g) C3a is a potent chemoattractant for neutrophils and monocytes. h) iC3b is an active product of the cleavage of C3b by factor I. CorrectWrong: b, c, f and h are true.Your answer has been saved.

3	Which of the following complement receptors induce(s) phagocytosis? a) CR1 b) C1qR/C1qRp c) CR2 d) CR3 CorrectWrong: b and d are correct.Your answer has been saved.