Immunity: Chapter 03, Innate Immunity

Table of Contents

1. 3-1 Barriers to Infection at the Epithelium
2. 3-2 Innate Recognition by Soluble Collectins and Ficolins
3. 3-3 Overview of the Complement System
4. 3-4 Activation of the Complement Cascade
5. 3-5 Complement Effector Actions and Receptors
6. 3-6 Regulation of Complement and Evasion by Microbes
7. 3-7 Recognition of Microbes by Phagocytes
8. 3-8 Mechanisms of Phagocytosis
9. 3-9 Destructive Mechanisms of Phagocytes
10. 3-10 The Toll-Like Receptor Family of Innate Immune Receptors
11. 3-11 Toll-Like Receptor Signaling to Cytokine Production
12. 3-12 Intracellular Sensors of Bacterial Peptidoglycan Components
13. 3-13 Inflammation: Initiation of an Inflammatory Response
14. 3-14 Inflammation: Recruitment of Immune Cells
15. 3-15 Inflammation: Regulation and Systemic Effects
16. 3-16 Innate Defense Against Viruses: Interferon
17. 3-17 Inhibition of Virus Replication by Interferon
18. 3-18 Innate Defense Against Viruses: Induction of Apoptosis
19. 3-19 Intracellular Defenses Targeting Viral Nucleic Acid

3-2 Innate Recognition by Soluble Collectins and Ficolins

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

The description opsonin is applied to molecules that have which of the following properties of collectins and ficolins? a) Carbohydrate recognition. b) Complement activation. c) Coating of particles and stimulation of phagocytosis. d) Circulation as serum proteins in the bloodstream. CorrectWrong: c is correct.Your answer has been saved.

2

Which of the following statements are true? a) Encapsulated bacteria, which mask their surface lipopolysaccharide with a polysaccharide capsule, can be recognized by collectins. b) Polysaccharide binding to collectins and ficolins triggers complement activation by inducing assembly of the collectins and ficolins with proteases. c) Collectins and ficolins can distinguish mammalian and microbial carbohydrates. d) The many globular heads that are characteristic of collectins and ficolins help compensate for the relatively low affinity of carbohydrate binding by each head. e) The L- and H-ficolins protect mucosal surfaces. CorrectWrong: a, c and d are true.Your answer has been saved.