Immunity: Chapter 03, Innate Immunity

Table of Contents

1. 3-1 Barriers to Infection at the Epithelium
2. 3-2 Innate Recognition by Soluble Collectins and Ficolins
3. 3-3 Overview of the Complement System
4. 3-4 Activation of the Complement Cascade
5. 3-5 Complement Effector Actions and Receptors
6. 3-6 Regulation of Complement and Evasion by Microbes
7. 3-7 Recognition of Microbes by Phagocytes
8. 3-8 Mechanisms of Phagocytosis
9. 3-9 Destructive Mechanisms of Phagocytes
10. 3-10 The Toll-Like Receptor Family of Innate Immune Receptors
11. 3-11 Toll-Like Receptor Signaling to Cytokine Production
12. 3-12 Intracellular Sensors of Bacterial Peptidoglycan Components
13. 3-13 Inflammation: Initiation of an Inflammatory Response
14. 3-14 Inflammation: Recruitment of Immune Cells
15. 3-15 Inflammation: Regulation and Systemic Effects
16. 3-16 Innate Defense Against Viruses: Interferon
17. 3-17 Inhibition of Virus Replication by Interferon
18. 3-18 Innate Defense Against Viruses: Induction of Apoptosis
19. 3-19 Intracellular Defenses Targeting Viral Nucleic Acid

3-1 Barriers to Infection at the Epithelium

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

Which of the following are properties of all three of the major groups of antimicrobial peptides? a) They are less than 100 amino-acid residues long. b) They are composed largely of a disulfide-bonded beta sheet. c) They are cationic. d) They are induced by innate immune recognition in Paneth cells. e) They are stored in specialized vesicles in neutrophils. CorrectWrong: a, c and e are correct.Your answer has been saved.

2

Which of the following statements are true? a) Mammalian cells avoid attack from defensins through positive charges on their surface molecules. b) Some bacteria avoid attack from defensins through positive charges on their surface molecules. c) Low concentrations of antimicrobial peptides can kill microbes. d) Antimicrobial peptides can act as chemoattractants for phagocytic cells. CorrectWrong: b and d are true.Your answer has been saved.