Immunity, Chapter 02, Signaling and Adhesive Molecules of the Immune System

Table of Contents

1. 2-1 The Immunoglobulin Superfamily: Structural Features
2. 2-2 Signaling by Immunoglobulin Superfamily Receptors
3. 2-3 Adhesion Molecules of the Immunoglobulin Superfamily
4. 2-4 Integrins in Immune Function
5. 2-5 C-Type Lectins and Carbohydrate Recognition
6. 2-6 Cytokines and Cytokine Receptors
7. 2-7 Cytokine Receptors that Signal via the Jak-STAT Pathway
8. 2-8 Shared Subunits in Subfamilies of Type I Cytokine Receptors
9. 2-9 The TNF Superfamily of Cell Regulators
10. 2-10 NF-κB and Inflammatory Cytokine Action
11. 2-11 Molecular Control of Apoptosis
12. 2-12 Regulation of Apoptosis by Bcl-2 Family Members
13. 2-13 Chemokines and Chemokine Receptors
14. 2-14 Chemokines, Integrins and Selectins and Immune-Cell Homing

2-14 Chemokines, Integrins and Selectins and Immune-Cell Homing

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

The arrest step in immune cell migration through blood vessels depends on interactions between: a) integrins and Ig superfamily adhesion molecules. b) selectins and carbohydrate groups attached to cell-surface protein scaffolds. c) chemokines bound to proteoglycans on the blood vessel wall and chemokine receptors on the migrating cell. CorrectWrong: a and c are correct.Your answer has been saved.

2

Which of the following statements are true? a) Expression of selectins is regulated in lymphocytes. b) Expression of glycosyltransferases required for generation of P-selectin ligands is regulated in phagocytes. c) Expression of P-selectin is regulated in tissues. d) Expression of chemokine receptors is regulated in lymphocytes. e) Expression of the mucin P-selectin glycoprotein ligand 1 (PSGL1) is sufficient for binding to P selectin. CorrectWrong: a, c and d are true.Your answer has been saved.

3

Which of the following steps require signalling to the interior of a migrating cell? a) Rolling along the blood vessel wall. b) Arrest on the vessel wall. c) Tight binding to adhesion molecules on the vessel wall. d) Transmigration through the vessel wall. CorrectWrong: b, c and d are correct.Your answer has been saved.