Immunity, Chapter 02, Signaling and Adhesive Molecules of the Immune System

Table of Contents

1. 2-1 The Immunoglobulin Superfamily: Structural Features
2. 2-2 Signaling by Immunoglobulin Superfamily Receptors
3. 2-3 Adhesion Molecules of the Immunoglobulin Superfamily
4. 2-4 Integrins in Immune Function
5. 2-5 C-Type Lectins and Carbohydrate Recognition
6. 2-6 Cytokines and Cytokine Receptors
7. 2-7 Cytokine Receptors that Signal via the Jak-STAT Pathway
8. 2-8 Shared Subunits in Subfamilies of Type I Cytokine Receptors
9. 2-9 The TNF Superfamily of Cell Regulators
10. 2-10 NF-κB and Inflammatory Cytokine Action
11. 2-11 Molecular Control of Apoptosis
12. 2-12 Regulation of Apoptosis by Bcl-2 Family Members
13. 2-13 Chemokines and Chemokine Receptors
14. 2-14 Chemokines, Integrins and Selectins and Immune-Cell Homing

2-13 Chemokines and Chemokine Receptors

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

Cell migration in response to chemokine signalling is sensitive to the pertussis toxin produced by Bordetella pertussis. The action of pertussis toxin is to: a) block association of the chemokine receptor with the heterotrimeric G protein through which it transmits signals to the cell interior. b) prevent cleavage of chemokines to the active form. c) inactivate the heterotrimeric Gi protein. d) suppress expression of the chemokine receptor. CorrectWrong: c is correct.Your answer has been saved.

2

Which of the following statements are true? a) The two major families of chemokines are distinguished by the number of disulfide bonds they contain. b) Homeostatic chemokines determine the normal populations of cells in lymphoid organs. c) Inflammatory chemokines can be activated by proteases released by monocytes. d) The gradients of chemokines that guide cell migration are due to graded expression of transmembrane chemokines. CorrectWrong: b and c are true.Your answer has been saved.